Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
P0CY20
3.1.3.7
ACT_SITE 54; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179"; ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179"
MSHTTHPYQKELEVATLAVKRASLLTKQLSDSIVQTARSGTLTKDDKSPVTIGDFASQAIINHAIKLNFPSDEIVGEEDSQELQENSSLADQVLSLIIKIQQETSVYNDVVGTLTDKNKVFQSIDYGNSQGGSKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGKVVLGVIGCPNLSENIVSNEEHSGVVGGLYSAVKGVGSFYSELFKEGTEPLSQQKPIKMQNHTNPSQLKVVEGVEKGHSSHSTQAEIKAKLGFDPTTVAKQTVNLDSQVKYCVLASGQADIYLRLPVSDTYREKIWDHAAGNILIYESGGQVGDVTGAPLNFGNGRTLDSKGVIAANKEIFDKVIDAVTEIRKSSTPRV
151
A0A2R6W0X7
1.11.1.7
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAQSGSFWAVFVVVAILGVAAANAQLSPTFYATKCPGAVAKSAEVVRTWILKDRSMAPALLRLHFHDCFVRGCDASVLLDSTIANSGEKDADGNKNSLRGFEIIDDVKAKIEALCPGVVSCADILALAARDAMQVFGGLNYTVPLGRRDGVSSFAWEANNNLPPPFADWTKLMSIFSTKGLSSKDLVVLSGAHTVGFTRCSTIQSRLYNFSTTIPTDPTLDPSFVPLLKSRCKFGSSGIVMMDLSKTTDTWDFNYYSNVLKGRSLFQSDDALKRTTEGLKLVQAENKAGGPFSADFAASMIKMGNIQVLTGTSGQIRKKCRVVNA
14
A0A8V0XZG0
2.4.1.18
ACT_SITE 343; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 398; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MAASGTQGPQAPKLPELLERDPYLAPFERDFQRRYALFYKRLKSIDDNEGGLNKFSKSYKSFGVNQFVDGGVYCKEWAPGAEAVFLTGDFNGWNPFSHPYKKMEYGKWELFIPPGQDGFSPVPHGSKLKVVIRAQNGELLYRISPWARYVVRYEGKVNYDWVHWDPPQSYIRKHRSPKKLKSLRIYESHVGIASPEGKIASYKNFTYNVLPRIRDLGYNCIQLMAVMEHAYYASFGYQVTSFFAASSRYGTPDDLKELIDVAHSMGITVLLDVVHSHASKNSEDGLNKFDGTDSCFFHSGPRGTHRIWDSRLFDYANWEVLRFLLSNLRMWIEDYGFDGFRFDGVTSMLYHDHGIGKEFSGDYNEYFGLDVDEDALCYLMLANHMINFLHPDCITIAEDVSGMPALCRPVAEGGGGFDYRLAMAIPDKWIKIIKELKDEDWNMGNIVYTLTNRRCDEKYIAYAESHDQALVGDKTLAFRLMDAEMYTNMSVFTPLTPVIDRGIQLHKMIRLITHTLGGDGYLNFMGNEFGHPEWLDFPRKGNNESFHYARRQFNLTDDHLLRYKFLNEFDRDMNKLEEKFGWLASPPAFVTEKHESNKVIAFERAGLLFIFNFHPYESYVDYRVGVEVPGNLTVFLSIKSLWILMLQNMEDIRGWTTIQSTSLKNILTIIDLIQLWCTFQAEWLLCFRIRMSHSEDLCNYH
73
B3SDM0
4.1.1.17
ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MVIIHQWKMRLRNVEIFYAMKCNNDPVLLRTLINLGVSFDCASLGEIQSILNAGVNPDRIIYANTIKAISHLRFAKEKNVNLTVFDNEDELYKIKKYHPNAKLAIRICPDMEVCESRFQLGIKFGAAKADVAHLLEVAQSLKLNVVGVSFHVGSDCLTPIAYEKGIITSKQIFKLAEKFGYHFNLLDIGGGFTAFSALETTFAKAAAVISKALQKYFPPELGVRIIAEPGRYFATRACTLVLNVIGRRVVRKGNGDLFDFEHENAHLYKNTNDFEKVLYYVNDSVYGCLNILPIDHALITLKPVKSNTHGEETAVLFGQTCDSLDCLMKECLLPKLNAGDWVYFEETGAYSLSLASKFNSFKKPKCYYYIQEHLWNEIQGKVNLPFNLTTN
195
I1ITK9
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASSFVKLSVALTCLLLLSSTCHGSHGPNVGHYKKTCPNAEAIVRDSVKSSVYKDAGVGAGLIRLLFHDCFVQGCDGSVLLDPSPSNPQPEKLSAPNFRSLRGFEAVDAAKAAVERACPGVVSCADVVAFAARDAAYFLSGLRVKADMPGGRLDGRVSRSDEAARDLPPASANLAQLVSNFAAKGLGEEDMVVLSGAHSVGASHCSSFVPGGRLEGPGRSDMDAGLAAVLKKQCAPGQNPLVPQDAVSPNALDSQYYRNVLAHKVLLPSDAALLAAPATEKMVRDNAYVPGKWEGKFAEALVKMAAIGVKTGQQGEIRKNCRVVN
14
A0A3B6C7J9
2.4.1.18
ACT_SITE 484; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 539; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MASPAFAVSAAGLARPSTPRSGGAERRGRGVELQSPSLLFGRNKGTRSPRAVSVGGSGWRVVMRAGGPSGEVMIPDGGSGGTPPSIDGPVQFDSDDLKVAFIDDEPSLQDEGEDSIWSSETNQVTEEIDVEGTNIMDKESSTGEKLRIVPPPGNGQQIYEIDPTLRDFKYHLEYRYSLYRRIRSDIDEHEGGMDVFSRGYEKFGFMRSAEGITYREWAPGADSAALVGDFNNWDPNADHMSKNDLGVWEIFLPNNADGSPPIPHGSRVKVRMDTPSGIKDSIPAWIKYSVQTPGDIPYNGIYYDPPEEEKYVFKHPQPKRPKSLRIYETHVGMSSPEPKINTYANFRDEVLPRIKRLGYNAVQIMAIQEHSYYGSFGYHVTNFFAPSSRFGSPEDLKSLIDRAHELGLVVLMDVVHSHASNNTLDGLNGFDGTDTHYFHGGSRGHHWMWDSRVFNYGNKEVIRFLLSNARWWLEEYKFDGFRFDGATSMMYTHHGLQVTFTGSYHEYFGFATDVDAVVYLMLVNDLIHGLYPEAVTIGEDVSGMPTFALPVQVGGVGFDYRLHMAVADKWIELLKGNDEAWEMGNIVHTLTNRRWLEKCVTYAESHDQALVGDKTLAFWLMDKDMYDFMALNGPSTPNIDRGIALHKMIRLITMGLGGEGYLNFMGNEFGHPEWIDFPRGPQVLPSGKFIPGNNNSYDKCRRRFDLGDAEFLRYHGMQQFDQAMQHLEEKYGFMTSDHQYVSRKHEEDKVIVFEKGDLVFVFNFHWSNSYFDYRVGCLKPGKYKVVLDSDAGLFGGFGRIHHTAEHFTSDCQHDNRPHSFSVYTPSRTCVVYAPMN
73
A0A3B5XW91
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKHCFSLAAALAVVTLAALLSSDAVVACIDVGFYDRTSPSAETLVQQTVAAAFGNDSGVPPAIIRLHFHDCFVKGCDGSVLIDSTPGNKAEKDSAPNFPSLRFFDVVDRAKAALEAQCPGVVSCADVLAFAARDSIVLSGGLGYQVPAGRRDGRVSTETDALNNLPGPTSTASDLVAGFAAKNLTVEDIVVLSGAHNIGVSHCSSFTERIYNFPNTTDGIDPKLSKAYAFLLKGICPPNSNQTFPTTTTLMDLITPARFDNKYYVGLANNLGLFQSDAALLTNATMKSLVDSFVRSEAAFRTRFARSMLKMGQIEVLSGAQGEIRRNCRVINPTNVTSAGAVHHHLLPRSSGSSGTNQVAAS
14
A9SZ95
5.1.3.3
ACT_SITE 181; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MGVSKGNLTEECVGDGVFLYTLERGGVRAVFTNWGATLMSLCVPDARGEIGDIVLGFDTLGPYTDGTSPYFGAIVGRVANRIARGTFILDGERFTLPVNNGPNSLHGGYVGFDKVLWEARKVTDGNGPSVQFTYHSHDGEQGYPGDLDVSVTYTLSSDCELRTEMEAKPVNKATPVNLAQHSYFNLAGHGSGDVLQHRVRLWSTSYTPLDDTQIPTGEIVPVRGTAFDFTEEASIGSRINDVPGGYDHNFDLRSGLEDPAGDLHPLNGGDLLGDGLRIAAKVWDPVSRRAMEVFTTAPGVQFYTGNYVDGIVGKGGAVYNIHAGLCLETQGFPNAVNDSRFPSIIVRPGETYRHVMVHKFYTQS
211
Q0U736
2.3.2.26
ACT_SITE 1815; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MTAHKSSNLDRVTRSAARRSTGSADDNTPNPNPPPPPPPPPPTRAPASNRKRKTAPPSSSPEPEAEQEEEAPARSSRAKRTKVDSQKKHARSKKAKGKAAMSAAESVPTAPQEDVRLTSDSQSNNPTDEKMSTPQPSSARRKGARKNDGSRRNPKTPGNDADPDAPSTSLRSSRKANNAEEDTAMEDAPEEQEDETRPPGEDSDEDDEEGPGGRYDEDDDEDDDDDDDPFSSGFLGRNPHSLAALRQLTGMMSGTTQRLRGILEQLRSVDVTMQLVALQELSETTWLAIFAPDAYVKELVKLMQPNEFTGEENPEVMLLACRCLANLMEALPAATANIVYGGAVPVLCSKLLEIGFIDLAEQCLSTLEKISVEFPSSIVREGGLTACLTFLDFFATSTQRTAVTTAANCCRNIPEDSFPTVRDVMPVLENILNNNSDQKVVEQACICVSRIVQSFRHQESKLEELVSKGLLKAILRLLLPGSTNMIGHNIHTQFLQVLAYTAKASPTLSAELLKMNVVDTLYQILTGVSPPSGAEDVAAKIDSVVIMQALIHRPKDQVYETLNVICELLPDVPKDGLLYLDDLRDAGYPGNEPQPLSTENKQTSNEKRIELLEGCKPEVKRFAVILLPTLTDAYSSTVNLGVREKVLSAQLKMLSNLDTDILEEALRSVPYASYLASIFSQQDHPSLVTYALQAAELLLKRLESIYRYQFYREGVISEISHLANRPSRTPEVQTKPKTTLEIEEAAESAPSSSSSGGDLDMEQEPIQDVEIETQSEDGDDDDGENEGRIETHDMQDDDDDSDSSSSSDRPEPPVVQNIEDIITLRAKKFLEVHEKDSDKPIRDKASAVLEDLKSLAKEIRGCIQEGTQSKCTELFTRLANYFEGDALDSITSYELKSSKIVDVLLEVFSTASPLSSVDHRAIFLEVFMGRSSQAKIKTASSASPATPFSSLVNKLQDLLSRSEHFEVFTVHQHAHDGRGGATSMLAKQLRLKLVADEDSGIPKSYRNIMVSIHAIAMFKALDDYLRPRISASERPRGSRTRDQFAAYAQALAEGRAPPPPHTPTDSTSRQAKKAAKSKSSPSDDSQAGPSSATRDKTRRSSRRQQNQLPPPPPPPPVIPRSNDDQDQVECADEERLSDDESMADTSALNAIVDDLEEELDEDTHDPSAVSVEVAPTGKATARKEDGTRISTPVQGTPMAKPPSETRTPSSRLSALLQDSALQRLGNAASALSYAAAVQSTPQDWHIEFSVNDQPISNDTTIYRAVHFSQSQPPEIAHRTVWNAVHTIKFKRVQGPPPTESSSLTPPPESASEASGMPASLDQHPVTSGILRLLSILHGLNAHLDDILSDNKDQIKHNAEPLSQFVNTKLTAKLNRQLEEPLIVASNCLPTWSEDLARFYPFLFPFETRHLFVQSTSFGYSRSMTRWQNSQPANDSRRDRHRDERPFLGRLQRQKVRISRSRILESAMKVMQLYGSSTSLLEVEYFEEVGTGLGPTLEFYSTVSREFSKKKLKLWRENESSEGEYAFGKRGLFPAPMSAAEAASINGERRLELFKTLGKFVARSMMDSRIIDVSFNPTFFRIGDSDTTVLPSLGAIKSVDEGLAKSLNLLKQFADAKYLVDTNDSLTSAEKTQALKDILVQDCRVEDLALDFTLPGYDTIELIDNGANTAVTINNVDKYFEHVLDFTLGSGVQRQVDAFRVGFSEVFPYSALKAFTPDELVMLFGRTDEDWTLETLMDSIKADHGYNLDSKSVRNLLQTMSEFKDQQRRDFLQFITGSPKLPIGGFKNLTPMFTVVCKPSEPPYSSDDYLPSVMTCVNYLKMPDYSTVDILREKLSVAIREGQGAFHLS
65
B3RLY4
1.11.1.24
ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1"
MVIAVGDKIPSYRLQQGSPGNNVDIAELVANKKAIIFGVPGAFTPGCHRSHLPGYVADYDKIVAKGVDIIICVSVNDAFVVDAWGKSVGAENKVVMLADPVAAFTKAIGMDLDATPILGNIRSKRYSMILSDGVLTNLNVEPDGTGLTCSLSNSILSQL
12
A0A059BWZ9
1.11.1.7
ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKAFVPSALFLVALHLISATVRAGGLPVEAYGLSFQYYQESCPNFEAIVSRKVKEWIKKDYTLAPALMRLHFHDCVVRGCDASILLNYPGSERSAAESKTLRGFEVINDIKVALEKSCPKMASCADILTSAARDATVLAGGPFWMVPYGRKDGRVSVAKEASKVPVGHENVTSLLQLFQSQGLNVLDLVVLSGAHTIGRSTCGSIQSRLYNYKSTGKPDPTLNREYGNYLKRKCRWASEYVYLDGRTPKTFDNMYYKNLQKKMGLLSTDQYLNSDSRTGPLVSALATQPELFNYQFGVSMAKLGNVQVLTGDEGEVRTNCNAVNRY
14
A0A078HP26
3.1.1.11
ACT_SITE 439; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAFQDFDKIQERVNANRKRKFRKRIIVGTVSLLVVVAAIIGGAFAYVAFEKQNEQEPKNNHKNDAKDSQKKSQSASPTPKAPVAAAQSVKPGQADKIIETLCSTTLYKVSCENTLKNRTEKGFAVESPTTFLKAAIEAVNEDLDRVLEKVLSLKTENQDDKDAIAQCKLLVEDAKEEIVASLNKVNGTEINNFVKIVPDLDNWLSAVMSYQETCIDGFEEGNLKSEVKKTVNSSQVLTSNSLALIKSFDANISPVEKVATRHLLDQIPSWVTNEDRRMLRAVDVETLNPNATVAKDGSGNFTTINDALKAMPEKYEGRYIIYVKQGVYDESVTVDKKKANLTMVGDGSQKTIVTGNKSHAKKIRTFLTATFVAQGEGFMAQSMGFRNTAGPDEHQAVAIRVQSDRSVFLNCRFEGFQDTLYAYTHRQYYRSCVIVGTVDFIFGDAAAIFQNCNIFIRKGLSGQKNTVSAQGRVDKFQTTGFVIHKCKITANEDLKPVKAEYKSYLGRPWKNYSRTIVMESTIEDVIDPIGWLRWEETDFAIDTLYYAEYKNKGPSGDTASRVTWPGFKVINKEEALNYTVGPFLQGDWINALGSPVKLGLYDA
125
P52496
6.5.1.1
ACT_SITE 304; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135"
MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYPSAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASRIISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMERFFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKHEMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFAGNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQFTTIDQYEQQTAYPFFLVFDILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCEGLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVIGKSPAIKNSYMCGLKSVTDGVYYSFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIHPSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHIKANYINDLNKAQTALGKKREPVYSLDNESKLKKVKVESDLFSGIEFLIMSDKREADGEVTTIEEMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRGCVLQLEPYFIFASKNWDNFNHMVDQYGDSYIIHHPLNIVVPKLSESELEDLRNGFDWGDLKPWIYLFKGLSFYVCGNNLSARFLKERIERFSGDLSKHFIECCYIVIPDNHSRPLMLREIDKMSNQISREMVIDKNGGSSRIPHFVTEAFVQASIKMNYIPDPDDYKFR
254
A0A9J7HGI7
2.7.11.30
ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1"
MTSVHVWLRLGLILYAAGLSLCAAVDTTCEFYDNSECENQENCNSTSRFVMCKDEQQQEEGKRSHCYALWKNESNVITLVKKGCWLDDNDCYDKSECYEHDEAPEKGMFYCCCEGNLCNQHFDHLPIPQPDRSTAETPRTVPVDNSKELFRSLMYSLFPICGIALVVAVTFYMYKRHKSEHIQCFTRHKTEHVQIPTQDPLPPPPSPLLGLRPLQLLEVKARGRFGAVWKAQLLNEYVAVKIFPLQDKASWLNEQDIFTTQLMKHDNLLQFIAVEKRGDGLEMELWLITAFHERGSLTDYLKGHLLKWSEMCHIAETMARGLAYLHDDVMGRNGEYKPAIAHRDFKSKNVLLKQDLTVVVADFGLAMKFDPGRSCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDMYAFGLVLWEIVSRCSAVDGPVDEYHLLSRYKIILPGSLNFIHVPLPLSPGPVDEYQLPFEEEIGQHPTLEDMQEVVVHKKMRPQFRETWLKHQGLEILCETIEECWDHDAEARLSAGCVEERLGQLSRTVNITTSNTVDITTNQQTPPKESSL
106
C6KSV3
2.2.1.1
ACT_SITE 415; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MNIMDNEIDTKCINEIRMLSAELPLEAKSGHQGAPIGCAPIAHILWSYVMNYYNEDTKWINRDRFILSNGHASALLYTMLYLTEQGLSMEDLKSFRQFGSLTPGHPENHITKGVEVTTGPLGQGASNAVGMAIAAHNLADKYNTEEHKIFDNYVYAICGDGCMQEGVFCEAASLAGHLGLGRLILLYDDNKITIDGNTDLSFTENIEKKFEALNWEVRRVEDGNKDYKKILHEIEQGKKNLQQPTLIIVRTACGFGTKVEGTCKSHGLALNDEDLKNAKSFFGLDPQKKFHISDEVKEFYKNVIQKKKENYIKWKNMFDDFSLKYPQVSQEIIRRFQNDLPNNWKDALPKYTPKDAPGATRNLSGIVLNSINKIFPELIGGSADLSESNCTSLKEENDIKKNSYGNKYIRFGVREHGMVAITNGLYAYGGFKPYCGTFLNFYTYAFGALRLAALSNHHILCIATHDSVELGEDGPTHQPIEVLSLLRSTPNLNIIRPADGNEVSGAYLSHFSNPHTPTVIALCRNKVPHLNNTQPEQVLKGAYILEDFDTSNNPKVILTGSGSELHLCFEAKEILKNQHQLNVRIVSFPSWTLFKKQPEDYQYSVMMHNHPNLPRFYIEPASTHGFDTYFNVYIGINQFGYSAPKNKIWEHLGFTPENIVQKVLAFMKNKLK
51
A0A1U8ME82
1.11.1.7
ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MNKYKMAELVLPMPFPLSISKASRMRNQALILLCIVVFGVIGTCHGGSLRKKYYKKTCPNAEEIIKTATEKHVANDPTLPARFLRMHFHDCFVRGCDGSVLLNSTTNNSAEKDAIPNLTLAGFDVIDDIKAEVEKKCPNVVSCADVLALAARDAVSFKFQRPLWEVLTGRRDGRVSRVSEALANLPSPFSNFTTLVRNFANQGLNVHDLVVLSGGHTIGVGHCNAFSNRLYNFTGRGDQDPSLNPTYAAFLKTQCRNLTDNTTFVPMDPGSVFTFDNNYYVTVKQNKGLFQSDAALLTNKGSRNIVNELVDPKKFFTEFAQSMKRMGAINVLTGNEGEIRKKCFVAN
14
Q9NLA1
2.7.11.1
ACT_SITE 172; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MPINYNRNAVELKLSSQLLQWLDQRLPLGDPMRIPSIDSYKYIQDLGKGRFGTVCKFSNGNTFETVKKVDLTIFNHWTQSETKVSNRLDTFLYEFRHLHKVTNDNNRIVNFLGIYADSNQMYIMSEYLPRGSVKDLLVKETLGEDTAIKYLMETVEALDYLHNLSPPVIHRDIKAANLLITSNDSIKLANFGLVRDLAVDGFGIAIASEITLDFRATLLYVAPEVLSSALGPGNRNAYELPADIWALGCTFIEMLLKRPPHFEYFGHIDEIPKVLLGYAKSEDGKVLPYTSEVLVPSSSNCVQKIVDLVFIKSPEHRPNTHKLRIQIKKILDDDSESEEETDISHPISNSNTDSSTAISHNHSNDRKVGRAGTCLPIESMEYAAVRKELKKRSKPKSNNIMQIFVASGYYLSRILYFLNILTRSICYLLLFLSLGITALGSFLLISYFVVRFVRYLIAINCNCDLMQPQYLIISGILIVLMFALLFSCCMVALGEYKFRMANQTLDGSKFYLPRPQKSAVLCGITVITGKEDAKDTAQNMEEEIHLTPSVRRNHDDYYYDESSGPANEEN
99
A0A3B3IGP2
4.2.1.11
ACT_SITE 251; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 384; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MTHTLPLPLLVIRFSHLLLFRLFLIHPCALLLSTRLQTNCRMSIVNIFAREILDSRGNPTVEVDLHTEKGLFRAAVPSGASTGIYEALELRDGDKTRYKGKGVTKAVSHINDSLGPALTQSGISVLEQEKLDNLMIEMDGTDNKSKFGANSILGVSLAICKAGAAEKGVPLYRHIADLAGNGELVLPVPAFNVINGGSHAGNRLAMQEFMVLPVGAESFRDALRVGAELYQTLRNVIKEKYGQDATNVGDEGGFAPNIQENSEALELIKTAIEKAGFTDKVVIGMDVAASEFFSEGKYDLDFKSPPNAARNISADELAGIYQGFINNYPVVSIEDPFDQDDWPAWSQFTASVGIQVVGDDLTVTNPRRIQRAVEEKACNCLLLKVNQIGTVTEAIKACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDQARYAGHNFRNPSAL
200
A0A022QXG1
1.11.1.7
ACT_SITE 51; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MNMMVKSGYGLSMNYYMMACPFADMVIRNTVNKALQSDPTLAAALVRMHFHDCFVEGCDGSVLIDSTKDNTAEKDSPANLSLRGYEIIDAAKDALERQCPGVVSCADILAMAARDAVFFAGGPFYDLPKGRKDGRRSKIEDTINLPPPTLNSSELITMFGKRGFTAQEMVVLSGGHTLGMARCSSFKSRLTNFDSTHDVDPNLDTQFARTLLKTCSGGDKAEQPFDSSRNSFDNDYFNALQRKAGVLVSDQTLFASAMTRGMVNAYATNQAMFFFDFQRAFVKMGLMDVKEGSKGEVRNTCRIIN
14
A0A022QAM3
3.1.1.11
ACT_SITE 370; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAKLSLFFFFFSYVCSHAVFADDDVSIKKGTISWWCSTTPHPDPCNHFIMMGRYNPNQHNPITRQDFRTLTIQAAMERAIHVQTRAKNLCFQGKSKRKKTVHRDCYNLIGNTIHQLNTTFRSIQKTSNATSDAQTWLSAALTNVEICRSGSHDLKIAARFRSPILSGYVSELISNSLAANGALILAANNDPDSGRRFPGRVTPGNRKLLQVSALVLKANVTVSPDGSGQFRSIQAAIDYATSKRVGDGRVVVYVKKGVYEENILINRTMNKVTLVGDGVKHTVITGSRSVSGGFTTYSSATVGVDGAGFMARGITFRNTAGPEKGQAVALRSASDLSVFYACAFEGYQDTLFVHAQRQFFKSCHIYGTVDIIFGNAAVVIQNSVIYVRKPLVGQANMITAQGRGDPFQNTGISIHNCRVMPAPDLKPVVGSFKTYLGRPWQQYSRTVIMKSYLDGLVEPEGWSRWGDSDFALSTLYYGEYKNFGPAGSLENRVNWTGYHAITNPDEASRFTVRSLVAGRAWLPATGVPFIAGL
125
Q8Y6W0
2.7.1.11
ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339"
MKRIAILTSGGDAPGMNAATRAVVRKAIYEGLEVYGINYGFLGLVNGDIRKLELGSVGDLLHRGGTFLYSARYPEFATEEGQLKGIEQLKKHQIDGLVVIGGDGSYHGAEALTKRGFPTIGIPGTIDNDISGTDFTIGFDTALNTVLDALDKIRDTATSHERTFIIEVMGRDAGDIALWSGLAGGAEAIIVPEESFNMDDVVDRLNKGRERGKKHSIIVVAEGVMSGNEFAKQLAEYGDYHARVTVLGHVQRGGSPTAFDRVLASRLGARSVELLLENRGGLAVGIRENRIVENDISEILKEKHTLDQKLFDLASILSI
84
A0A0A0KNT4
3.2.1.52
ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MFNSRNFFLFLIFPLPLLVPSALADLSQSGFNDSLPYLWPMPSDFTFGNSTLSVDPRLSLLAAGNAGNSEILKAAFDRYRGIIFKHASGVSMLDKLWGRRRTFVYDISELKIDVQSDSEELHLGVDESYTLLVSKKDAHSIIGEATIEAATIYGALRGLETFSQLCTFNYETKDVQIYQAPWYIKDNPRFAFRGLLIDTSRHFLPVDVIKNIIESMAFAKLNVLHWHIVDEESFPLEVPSYPNLWRGAYTKHERYTIEDAYEIVAFAKMRGINVMAEVDVPGHAESWGIGYPDLWPSPSCKEPLDVTKNFTFDLISGILTDLRKIFPFELFHLGGDEVNTDCWETVPHVKQWLLDQNMTTKDAYEYFVLRAQEIAISKNWTPVNWEETFINFEKGLNPRTIVHNWLRGGICPKAVADGFRCIFSDQGVWYLDHLDVPWDRAYHADPLEGISDPSQQKLIIGGEVCMWGETADASNVMQTIWPRAATAAERLWSKNETVSGNITLSVLPRLSYFRCLLNRRGVEAAPVKNFYARRPPTGPGSCYDQ
170
Q9C927
3.1.3.2
ACT_SITE 260; /note="Proton donor"; /evidence="ECO:0000250"
MSLETFPPPAGYNAPEQVHITQGDHNGRGMIISWVTSLNEDGSNVVTYWIASSDGSDNKSVIATTSSYRYFDYTSGYLHHAIIKELEYKTKYFYELGTGRSTRQFNLTPPKVGPDVPYTFGVIGDLGQTYASNQTLYNYMSNPKGQAVLFAGDLSYADDHPNHDQSKWDSYGRFVEPSAAYQPWIWAAGNHEIDYAQSIGETQPFKPYKNRYHVPYRASQNKYTPQNSWLQDEFKKVNRSETPWLIVLVHAPWYNSNNYHYMEGESMRVTFEPWFVENKVDIVFAGHVHAYERSERVSNIQYNITDGMSTPVKDQNAPVYITIGDGGNIEGIANIFTDPQPSYSAFREASFGHALLEIKNRTHAHYTWHRNKEDEAVIADSIWLKNRYYLPEEETI
145
W5MAF3
3.2.2.27
ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
MIGQKTINSYFNPVNKKRALEENNEAGEDAKEKKAITPVKRQKTASDGAPTSPPLSPEQLGRIERNKRAALERLAARNVPEGFGESWKKELCAEFGKPYFIRLMSFVAQERGRHTVYPPSHQVFTWTQMCAIRDVKVVILGQDPYHGPGQAHGLCFSVQRPVPPPPSLENMYKELSTDIEGFQHPGHGDLTGWAKQGVLLLNAVLTVRAHQANSHKDQGWEQFTDAVVLWLNRNLEGLVFMLWGAYAQKKGIVIDRKRHHVLQAVHPSPLSVHRGFFGCRHFSKTNELLVKAGKSPIDWEAL
173
Q89KG1
3.4.21.92
ACT_SITE 106; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 131; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGEKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVKHTGQTYKTIEDALERDKFLTANDAKEFGLVDRVIDKRAEEPAAAKTQ
179
O80719
2.7.11.1
ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSCFGCCGEDDDMHKTADYGGRHNQAKHFPPGNDARHHQASETAQKGPPVVKLQPIEVPIIPFSELKEATDDFGSNSLIGEGSYGRVYYGVLNNDLPSAIKKLDSNKQPDNEFLAQVSMVSRLKHDNFVQLLGYCVDGNSRILSYEFANNGSLHDILHGRKGVKGAQPGPVLSWYQRVKIAVGAARGLEYLHEKANPHIIHRDIKSSNVLLFEDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLNAKSDVYSFGVVLLELLTGRKPVDHRLPRGQQSLVTWATPKLSEDKVKQCVDARLGGDYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLNARAVAPGEGVH
99
Q8MT28
5.1.3.3
ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 328; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MVNVTEDVFANGAVNPFTKSKDTIKRFTLTNGAGMSVQLITRGATITSIKTPDASGQIDDVTLGFDDLAGYQSERNPYFGATIGRVCNRIANGSFYLDGKLVQVSKNRDNKFQLHGGFVGFDKAHWEVVEVRVDGVTLSHTNPDGHEGYPGKVTATASFTLSEDNCLHVQMSALADKTTPVNLTNHSYFNLAGHKSGANGLYEHTIKINAYGITETDQSSIPTGRITPVEGTGFDLRVSSNLGERLKALQPARGYDDNFCVTFSPPQPLAKVARATHPPSGRWLEVVSNQPGVQFYTSNFMPDVERGESPIPGKDGAAYAKHCAFCLETQKFPDSVNHSNFPSTILRPGESYQHEVIYKFGVSH
211
Q6IE06
3.4.21.4
ACT_SITE 55; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"; ACT_SITE 100; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
MKLVFCILSTLLGTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVLIHPLWVVTSAHCNLPDLRVILGITNPADTTEHDVEVSDYEKMFRHPYFSVSSISYDLMLIKLRRGIKHSYYAKAVKLPQHTVPVNAMCSVSTWAYNLCDVTKEPDSLQTVNVSVISKAECHNAYKAFDIRENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRADVGIYASIFHYMPWIENIMKNN
177
Q9U969
3.1.1.5
ACT_SITE 985; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1105; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
MDVLEMLRASASGSYNTIFSDAWCQYVSKQITATVYMYFALVMMSLLFIAWFLYFKRMARLRLRDEIARSISTVTNSSGDMRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPVFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQTSQSSRQAPNGPPMVISQMNLMQSAVSGTGSSGVSVTVTRPPSSPSRHSREEHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSITLMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSLRKELGLSEEDSHIIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEANPVTHKYSTVALVPITDEVPMTPFTYELYHSLCAIGPVLRLTSDVVRKQLGSNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEASNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRLGRFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCRLPETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVSRAGNSLSFSETEMDSDVELDLKLERKTDKSTQSSPPSNSRSDMRGKEEARHMSNWHWGVKHKDETGSGATEATKTQTGQEQELQQEQQDQGATAEQLVDKDKEENKENRSSPNNETKN
131
P36614
3.1.3.16
ACT_SITE 112; /note="Proton donor"; /evidence="ECO:0000250"
MFDLDEWIATVRKCKYLPEHQLKRLCEMVKVILMEESNIQPVRTPVTVCGDIHGQFYDLLELFRVGGELPSTNYIFMGDFVDRGYFSLETFTLFMLLKARYPDKITLLRGNHESRQITQVYGFYDECQTKYGNANVWKYCCQVFDFLTLAAVIDNKILCVHGGLSPEVRTLDQIRILARAQEIPHEGSFCDLMWSDPEDIESWTVSPRGAGWLFGSKVTTEFSQINDLTLIARAHQLVQEGYKYHFADKNLVTVWSAPNYCYRCGNVASVMKVDESLEPEFRIFSAVADEDRTVPPSRKRSEYFI
144
W1P6A4
3.5.1.98
ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MERSSGIALSSGPDAVKRKVSYFYDPGIGNYYYGQGHPMKPHRIRMAHNLIVHYNLHHLMEINRPCLANTDDIMKFHSEDYVNFLQTVTPETQHEQMRQLKKFNVGEDCPVFDGIFNFCRASAGGSIGAAVKLNRGDADIGINWAGGLHHAKKCEASGFCYVNDIVLGILELLKVHRRVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGHLKDVGFGKGKYYALNVPLNDGMDDESFQRLFRPVIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVRGHADCLRFLRSFNVPLMVLGGGGYTIRNVARCWCYETAVAVGVEPDNSLPYNEYYEYFGPDYTLHIDPSNMENQNSPKDLEKIRAVLLEQLSRVQHVPSVPFHSRPPNFDLPEEEEEDLERRPKCRRIWDGDYCASESEEDQRPRENDANDRDQSVGNSPARRVTTKTQTAVNEKQGDEETEMPDALDEKGENDETDENDESTE
184
Q5KNA0
3.5.1.2
ACT_SITE 102; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 228; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 230; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 454; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"
MAATQLPILEVGQPKGHSPQTKPKLYILDYGAGNVRSLANSINKLGYEFEWIKDESDFDKAEKLIFPGVGSFAQATSSLRTSGLHSRLLKYIASGKPYFGICIGMQVLFSSSSESPGSEGLGVVPFAITEFKVEDNYEGGNGRKSVPHMGWNKAWKAWKSEGDEKGTETLMVDDDYYFVHSYAALLPDPSASAPPNEVADFAYTLSRYGSETFISSIRRDNVFAVQFHPEKSGPAGLDMLKRWLDAPVDSLSSSPANPASTSVGKTWQPVNPSPLRAKGNGLTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVAFLNITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFRSGADKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVDTSAPGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQGVERLGAGEILLNSVDRDGSGQGFDLDLVKLVKNAVGIPVVSSSGAGSPADFEEVFRETGTEAALAAGIFHRGEVGIDEVKGWLEGKEMAVRKTALPTV
181
W5MQK3
2.7.10.1
ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1"
MGSVSGWRSTGAWGISASRMSTWACLLYLALVSMATVSLARPPFNTEEETTLEPEEPPTKYQISKPTVCSVHPGDLLKLSCPLPEAGTITWTKDGSSLGSNNRTLIVEESLQIRDATPKDSGLYACSTVSPIGSDTLCFIVNVTDAISSGDDEDDTERSEDVPGDGEQMRAPYWTMPEKMEKRLHAVPAANTVKFRCAAGGNPRPHLRWLKNGRNFRQEDRMGGYKVRHQHWTLIMESVVPSDKGNYTCVVENQYGSINHTYTLDVVERSPHRPILQAGLPANTTVRVGEDARFVCKVYSDAQPHIQWLQHIEKNGSRYGPDGQPYVRVLKTAGVNTTDKEIEVLSLPNVTFEDAGEYTCLAGNSIGISYHTAWLTVLPADPEEPIFGPTSPDYVEIAIYCIGVFLIACMVVIVVVCRMKNTAKKPDFSSQPAVHKLSKQIPLRRQVTVSADSSSSMNSSTPLVRITTRLSSAVDAPMLAGVPEYELPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEALTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVPDEQLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPGNCTNELYMMMKDCWHAISSQRPTFKQLVEDLDRILTLTTNEEYLDLCAPAEQYSPSFPDTRSSCSSGDDSVFSHDPLPDEPCLPKFQHMNGSVKT
97
Q54LR6
2.7.11.1
ACT_SITE 429; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MGKYYQIFFLLYLLCILYVISCGYINPYSPYSSPCLFAPIIGYLYMGGSLSSNSSNNNNNNNNNNNNNNNNNNNNNNNNNNKDSKLTENCNNNSSNNNSDNKSNIKNKQHHHHSNFRNRRGKSNNKNSSDNDDCTKCNKRHHTQSSSYDTSELHQSVSSGLGGSMGSGSQALTDIEKDINEFMNANPSHSLNKQQIQQQQQLQQQQQQLLKQQQQQQQQQQQQQQQQQQQQLEKQRKEQEETEKKKQLELQQQQQLQQQQQNGNGLIIEEDMMEGRILRNISKVYRDVNENQPKSYYDYEGYRINWKNVDRYEVIQKIGRGKYSEVFSGIDIETSDEVVIKVLKPVQKLKIQREIKILESLNGGPNIIPLLDSVKDQSSKVCSLVFPFVNKTDIRELVYTLDDYDIRYYIFELLKAIDYTHSKGIIHRDIKPLNIAIDHSKRKLSLIDWGLAEYYHPGKNYNVRVASRHYKPPELLVNMFDYDYSLDMWSLGCLFAGLILDRDPFFNGDNNNDQLLKIVKVLGTDDLFNFLDKFGLSLTDEQSSLIKPRQKSNWERFIPYENDDIAQPDAIDFLDKLLRYDPTERLTAKEAMKHPYFKDFNQSIL
99
Q9SVY5
2.7.11.1
ACT_SITE 191; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MKKQYLKSGSGTRKEKDKAKRWFLDNGSIFLRELVADCNGKSIPIRSFSPEQILKATNNFDSSCFVSQDVYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSGQRLQVEACVVLALRCCKERDEDRPKMIQVAKELKQIEASLKNSS
99
B9S005
3.1.1.11
ACT_SITE 405; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTIAKVIVGGISIILVVGVCIVLIAGLSNNTDTSAPDENDDNKILSATSMAVAAFCNQTDHKHRCVDSVFSVARNQSATFNDFLKAAISYTIEHVKLAMDTAATIGKDAKDSTQKMAVEDCQELLQFAIGELQDSLLTVKNSSFDAVKEREADLKNWLSAVMSYKETCLDGLNDTNLHKPMSDGLVNATELTSNALAIVSAISDIGNAFRIPSNLNASATRRLMEAEDDGFPFPTWMPNADRKLLGSATNANVKPNAIVAQDGSGQYKTIAAALAAYPKDLVGRYIINVKAGVYDEYITINKDQVNVFIYGDGPRKTTVTGDKCNKKGFSTFKTASFSAVGDGFMAKSIGFQNTAGAKGGQAVALRIQSDRAALYNCRMDGHQDTLYQHAHRQFYRNCVISGTVDFIFGDATAVIQNSLIIIRTPDPGQRNAVTAHGRADKRESTGLVIQNCRILPEQSLFPVISEFPSYLGRPWKQYARTVIMESEIGSVIQPAGWLEWTGNLYLDTLFYAEYGNRGPGANTNLRVKWKGYHVLTDKSEVTQFTAGPFLQGDQWLQATGFPYLLGLKSP
125
A0A1S4DB76
2.3.2.26
ACT_SITE 1062; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MYQFDAVNNRSTTVYNRSTTTTYKRRLDQIVSSESLAPSPIRMRKDQTLPPSPPIPVQFFVRLFPGGKTLVMRAHSTDPVEFIHHKIMTITGIPAVEQRLIYRGKQLQPEQTLADCGIQKDESMQLVGRLRSVDHPQARQLINGLISLIFDILKSKNPSIPSDSDGIIRMLVGFLTMTPKDTIEKAAEHIKIFISSSAPTALVMLYMSPDGANKFTADKSVRSFISSFKSMLPKRMYILCTPIVLQFCKLLRGAGLDDSLYKFCRSSLGDIVESTGILRRKATTGLLAVKDEIVSSESLVSSPVRMLKDLIRVQFFVRLFPGGKTLVIQAHSTDLVEFIHYKIMRITGIPTADQRLIYKGKQLQSEQTLANCGIQKDESMQLVGRMRSTDHPQAWQLINDLVSLIFDILKSNYPSVPSDSDHIIRTLIQFLTMTPGDNIEKAYEHIKIFVSSSAPAALVMLFMSPDNANKFTADESVRSFVNSFTSMLPKHICVGCARIVLEFCKLLRGAAGLDDCLYNFCRSSLGAIVDSIGIARHTKELLALKDVFVFVCEVVVPELSHALELSKGSVESTGGLSVSIVRDFTEYMLALKKVIPSQILFGTSEAVCVRECIKCLHRILYGLLDKMELCLNKLEAQLGLKEIGKGKPIVPWWSQYLVILKELNSISKLFKGLEKIFWQKMKQSKVSLCFLIVASAKRSNDYRWVLEHKEVTNFEVRRHFAMMMLREVRYGNQALHEMLIDRSQLLEESFEYIRHADPALLRGSLFMEFKHEEATGPGVLREWFFLVCQAIFNSQNALFIACPNDRRRFFPNPASKVDPLHLEYFCFSGRMIALALMHKIQIGVVFDRVFLLQLAGEEISLEDIRDADPYLYSSCKQILEMDPETVDQDILGLTFVCEVEELGSRKVVELCLDGKDTVVNSKNRKKYVNLLIQHLFVTSIAQQVAHFSQGFADITTSRLQTSFFRSLDLEDLDWMLDGNGSAVSVEEWKAHTDYKGYKESDPQISWFWKIVGRMSAEQRKVLLFFWTSIKHLPLEGFGGLASRLYICRISESYDHLPSAQTCFYRIRFPPYQSMAVMQDRLRVITQEHVGCSFGTW
65
P25765
3.2.1.14
ACT_SITE 147; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022"
MRALAVVAMVATAFLAAAVHAEQCGSQAGGAVCPNCLCCSQFGWCGSTSDYCGAGCQSQCSAAGCGGGGPTPPSGSGGSGVASIVSRSLFDQMLLHRNDAACPASNFYTYDAFVAAASAFPGFAAAGGDADTNKREVAAFLAQTSHETTGGWATAPDGPYAWGYCFKEENGGAAGPDYCQQSAQWPCAAGKKYYGRGPIQLSYNFNYGPAGQAIGADLLGDPDLVASDATVSFDTAFWFWMTPQSPKPSCHAVATGQWTPSADDQAAGRVPGYGVITNIINGGLECGHGEDDRVADRIGFYKRYCDILGVSYDANLDCYSQRPFGS
158
Q8F290
1.8.1.4
ACT_SITE 451; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGICLNWGCIPTKALLESAHLLEKLHSAKEYGINLSDPKPDFAAIIRRSRNVADGMASGVEFLLNKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATGARARELPGLPFDSHTVLSSKTAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSFVKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLEEIGIFLQKGFVKTDTKYKTSVPHIYAIGDCNGPPLLAHVASMEGIKAVEAISIHAGNPHHLSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISVGKFPFVASGRAKAMGDTGGFTKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESFGAALGEAINL
36
A0A9J7HUC7
3.1.1.4
ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MVVFGATAPVVLLGFLVAASMSQPVDQPEDQPVDQLVDYPVDHLEGQPRSRAKRDLFSLSGVIRCVTGNSALLMYNNYGCFCGRGGGRGRPVDDIDRCCVAHDRCYALPTWFNALFVIYPYRCIGSKVTCTSRNWLRRSVCECDKALAECFARSVYNRRFKNYPYCGALQPEDPAVDTGKEPAVDAGKETPVDAGKDEKPWIGSGDGYDRFLSQRVRVGKRVIIGQWPL
130
A0A2K3D1P1
1.1.1.37
ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MASSTSSAMAKWAAQAARGFAAAAPSSGKGRKVAVLGAAGGIGQPLSMLMKMNSQVSSLSLYDIAGTPGVAADVSHINTKAQVKGFDKDGLAEALRGCDLVIIPAGVPRKPGMTRDDLFKINAGIVRDLVTAVGQHCPGAVLNIISNPVNSTVPIAAEQLKKMGVYDKRKVMGVTTLDVVRAKTFYAEKNGLDVASVDVPVVGGHAGVTILPLFSQATPKATMSAEVLDALTKRTQDGGTEVVQAKAGKGSATLSMAYAAALFADSCLRGLNGAPVVECTYVESTVTDAPYFASKVKLSTEGVDKIHDLGPLSDYEKAGLKAMMPELLASIEKGVQFVKGA
5
F6Y7X8
2.7.11.1
ACT_SITE 326; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 343; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MNYREQLMSRAVPGQFDDADSSDSGSMVSMETSKDAQAVSENSHQPLNEVDEEIQENDFEEYEDYDDDDDDWDWDDEVGKLTKGFSSSGGSNPQVNRQTNHLNSSKMSTPADKALRKFENKINLDKLNLADSVINKVTEKTRQKDADMYRVKDKADRATVEQVLDSRTRITLFKMLSRGIISQINGCISTGKEANVYHASTTDGENRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVQTWAEKEMRNLIRLNIAKIPCPEPIMLKHHVLVMSFIGKDDMPAPLLKNAQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYCNGDVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFLKHSVAVMTVRELFEFITDPSITKDNMDDYLLKAMEIAGQRTEEQRSNQDHVDEEVFKRAYIPRTLNEVKNYERDVDIMMKMKEEDMALNVQQDNILYQTVTGLKKDLSGVQKVPALLEKQSEQVDSDSENTSDSEEPDSEEHGDQPHPRTYPIDHEMDKKERKKIVKEAQREKRKNKIPKHVKKRKEKVAKMKKGR
99
G7J4T5
3.5.1.98
ACT_SITE 162; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MGSGEMGVAESGGASLPSIGADAMKRRVTYFYEPSIGDYYYGQGHPMKPHRIRMAHNLIIHYSLHRRMQINRPFAAAPEDIRRFHSDDYVEFLSSVSPEIVSDNSHSHYRQLKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVRLNRGDADIAINWAGGLHHAKKAEASGFCYVNDIVLGILELLKVHRRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKFGDFFPGTGHIKDTGVGPGKDYALNVPLNDGMDDENFRALFRPIMQKVMDVYQPDAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSFNVPLMVLGGGGYTVRNVARCWCYETAVAVGVEPSNKLPYNEYYEYFGPDYTLHVEPNNMENLNTPKDMEKIRNTLLEQIARLPHAPSAPFQTTPSTAEVPEVEEEDMDIRPKRQLWSGEDYDSDPDEDEKANIRSSSLTSHMRRAADMMEEDKPEVKPGVHPPC
184
Q0U1W6
1.11.1.6
ACT_SITE 95; /evidence="ECO:0000256|PIRSR:PIRSR038927-1"; ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR038927-1"
MASQILATASHVADKAKEMTGVKNAKVAQLQADTKDVHDPKWKMTSDYGVKQNNTDDWLKVATEDQQGPMLLEDHFAREKIQRFDHERIPERVVHARGSGAFGKFTLFESAADVTSAGVLTDTSRETPVFLRFSTVLGSRGSADTVRDVRGFAVKFYTEEGNWDIVGNNIPVFFIQDSMKFPDVIHAGKPEPDNEMPQAQSAHNNFWDFQYMHPEATHMFFWAMSDRTIPRSYRMMQGFGVNTFTLTNDKGERSFVKFIFTPELGVHSFVWDEALKIAGQDPDFHRKDLWTAIENGAYPKWKFGIQVIPESKEHDFEFDILDATKVWPEELVPIRYIGQLELNKNPDEFFTQTEQVAFCTGHVVPGIGFSDDPLLQGRNFSYNDTQLSRLGVNWQELPINKPVCPVMNFNRDGAMRHGITKGKVNYWPNRFESAPPAKASEGAYIDFPAKVAGIKARTQSKKFREHKNQAELFYNSLSEPEKMHAMNAFAFELDHCDDPLVYNRICERLCEIDLELAQKVSEMVGGDIPTTQTRTKHNKTAKGLSQLDFPPEKPTIATRMVAIIIADGYDKVAYEGIKAALTAAGALPFTISPRRNNIFAEGEDKSSGGVKADHHLEGMRSTMFDSVFVPGGAKSVETLSKNGRAIHWVREAFGHLKAIGATGEAVAFVKQCVDLPDMQFSTAGDVVESYGVVTASKVQPENFKETLQMAKGAKDFVSAYAFAISQHKNFDRELAGLNAMVAY
13
H9GEE3
2.3.1.48
ACT_SITE 890; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MVKLANPLYTEWILEAIQKVKRQKQRPSEERICHAVCVSHGLDKKSVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFLPVKVCDLSKPSKGSKGTCSELRNVDWNKLLRRGIEGLQEPNGSSLKNIEKYLRSQHDLAGIFNDPVFQRRLRLGAKRAVNNGRLLKEGPQYRVNYGILEGRGTSRYSSFPISLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCLELTTNVKALRWQCIECKTCSACRIQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGGKLLHEKASQIRRRYAKPIGRPKNKVKQQMLSVTSDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASVKESSSRLAVTDPTWPGATTTKITNTTSTYISASTLNVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKMASQKQTCTSHVLATGTTQKLKPSSLPPPNPISGQSPSSQKSSTSISSNSPQSSSSQSSAPSFSSLPSNTQLKGLFDGLSHIYATQGQSRKKGHPSYAPPKRLHRKAPFSSTSKSNTAFCGKKEIRSRFISHSSTSGWGMPRGLAFKAIAHFKQSTFLKKRMILGRLKYKVTPQMGTPSPGKGNLADGRIKPDQDDGTEIKISIKQENADLFLVGSKDFVTEEDLEIYKQAQELAMEKIGCKIGGETNGRYPSVIEFGKYEIQTWYSSPYPQEYARLSKLFLCEFCLKYMKSKNILLRHSKKCGWFHPPASEIYRRKDLSVFEVDGNASKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQYQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRVSYLAYWKSVVLEYLYCHHEKQISIKGMSRATGMCPHDIATTLQQHRMIDRREEKFVVIKREKLISSHMEKLKTNPRINEVDPESLRWTPLLVPNAAVSEEEREAEKEAERLMEQASCWEKEEQELFSKRANRQLSAKVQSKNKYLRPTENVSAIAEKGQATDPPKESSGDEEEEEEEEEEEEIMDGHHQNSSPRLAKLQLLAMKRKRSFVLKKKRGRKRRKINSSVTTETISETTEVLNEPFDNLEEERPMPQGESTFEIDGESDELKAGIQEVFQSPSEEREENEQEKEEQEKDNHSYQNDTAYRAKAEDSAAILEDVSKDNPEPVVCKQAWPKGMKHYPSKWRQSKERKFGFKLNLYTPPETPMEPDYQLMGEESKEPAESNPSQDSAVTEEVKNSETILPCEDEAGDSASEYLELSRTEKTENDLEEVEENNTVEEVESVNSQSKNQQETTEMEKEEPEPLDHDEEEEEGKSRNEDHDADDEDESHVCSAEIETQEAAPEEPLKEVLENQESFLGEHEHSVKSSQEDAIDCTVDLVNECNSDQKEFPAVLESASEPSNENTEDQNQVENAELNSAFKNTNTETLEIDSETAQAVKSLTQETAEHEDAFQDSAETQEACQSLQTYTNTNESPQISTLDDCQQSDHSSPVSSVQSHPSQSVRSANSPNVPPLENSYTQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGNSICTNNSSQNSCSYSNLTSTSMTQSSCAVTQQMSNMNGSCSMMQNTSINSPPPCNVKSPQGCVIERPPSSNQQLPQCSMAANFSPPMQLSEIAETGNANIGLYERMGQGEFAAGHYPQPSATFSLAKLQQLTNTLMDHSLPYSHSAAVTSYANSASLSAPLSSTGLVQLSQSPHPVPVGGQVQTTMTPPPNLTPPPMNLPPPLLQRNMATSNIGLSHAQRLQTQMPGKGHVSGRTKSAPLPPAAASHQPQIYGRASQTVAMQGPARALTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPIMNGGYHANHGYMNQTAQYPMQMQMGMMGSQPYAQQPMQTTPHSNMMYTPPAHHGYINTGMSKQSLNSTYMRR
61
W5MNH5
2.7.10.2
ACT_SITE 486; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000604-1"
HLVMADKVNELRFFYGNITREEAEDYLRQSGMSDGLYLLRQSRNYLGGFALSVAYSRQCYHYTIERELSGTYAIAGGKSHKTPSDVIDYHAQESDGLVCLLKKPCNRPRGMQPKVGPFEDLKEQLIKEYVQQTWNLRGAALEQAIISQRPQLEKMIATTAHEKMPWFHGCISREGSEPRLLQSPRINGKFLIRERDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPDGKKFDTLWQLVEHYSYKSDGLLRVLTEACPRPDFAAGSINIGPPRLPDHHPDTVYTIATNIYVECRIKNIRLRVISLLPSRGHAATAHQNTYEPSVARNKIKEAMPMDTSVYESPYADPEELKPKTVHLDRKQLYLEDGELGSGNFGKVMKGIYKMTKTEKPVAVKILKNDDNDPAVKEEMLREANVMQQLDNPYIVRMIGICDAENLMLVMELAELGPLNKYLQKHKHITVRNITELVHQVSMGMKYLEDNNFVHRDLAARNVLLVTQHYAKISDFGLSKALAAEENYYKAKTHGKWPVKWYAPECINFFKFSSKSDVWSFGVLMWEAYSYGQKPYKGMKGNEVLQMIERGDRMEAPAECPSEVYDIMRKCWTYKTDERPGFHAVEGRLRDYYYDISQ
98
A0A2R6W884
3.2.1.52
ACT_SITE 408; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MSSSSHRCNGKKYKSIEDEPVTSFPHLSINMLFRLYNEDSRVYGPVNPLLINKLRLQRAMAHQAVMCTSTSWSWTWRFIVFILILLQVAVADVFLWPEPQTVRWESGARIVLNPAFEISAPDHPELSSAVARYAALIRTERWYPVQVPRSVVITRKAGTDSEVVILNVFVVDLAADLQHGVDESYTIEISPTSSNASLSAGTVWGAMRGLETFSQLLRVAEPSANAPLYIERGVFISDKPNYPHRGILLDIARNFFPVEDIKRTIRALSHNKLNVLHLHITDAQSFPLEIKSEPDLAVKGSFGPQFIYYQEHVVDLVRYGRRHGVRVIPEIDAPGHTASWGGAHPDIVTCLDEFWLPNPADWSQRLASEPGSGQLNPLMDKTYEVVKNVIDEVAALFSDHFFHAGGDEVAPACWKRSDLVTDFLARPNDDARNNTLSDLLTTYIERTRAMIDVHNKTAVYWEDILLGAEVKVQRASVPAATTILQTWNNGPLNTKTLTAAGYRTIVSSNDFFYLDCGHGGFLGNDSQYDQNFNDDPTSTVNYGGRGGSWCAPFKTWARIYDYDITANLTEDEAKLVLGGEVALWSEQADETVLDAMLWPRSAALAESLWSGNRDPADATKKRSGDAIDRLNDWRFRLVHRGINAEPLQPLWCLKNPRMCNSVY
170
B2U8Z4
1.3.3.3
ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MDTQAVRAYLLDLQDRITTAASALDGGTFVTDAWEKPPTERLRGSGRTRILEGGALLERGGVGFSHVMGDTLPPSATANRPELAGRGFEAMGVSLVFHPRNPYVPTVHMNVRCFVAVRSDAAPVWWFGGGMDLTPYYGFTEDASHFHRTCQGALAPYGDELYPRFKQWCDDYFYLKHRKEARGIGGIFFDDFAELGFERSFEMMRSVGDAFLPAWLPIAEQRHATAYGERERAFQAYRRGRYVEFNLVFDRGTLFGLQSGGRAESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDWV
27
Q6AUK5
1.8.4.12
ACT_SITE 212; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126"
MGVQHLLKLRMASPHPHPHPGAPLAARPLSALASFFLARPSSTAAAPPPRHVTLSCSRPHCNHNQWAASRCRGTAGRRRLQVVVAMSSSAPPPPPGSVQKSEEEWEAILSPEQFRILRLKGTEYPGTGEYDKLFAEGVYECAGCGTPLYKSSTKFNSGCGWPAFYEGFPGAIARTPDPDGRRIEITCAACGGHLGHVFKGEGFNTPTDERHCVNSISLKFIPASEDSKL
40
A0A8I6GL04
2.3.2.26
ACT_SITE 879; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MATGLGEPIYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
65
A0A072TSM6
1.11.1.7
ACT_SITE 117; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAPPLILPKLILLILVLCLLFQHKNHNKNTNSNANTFNSINIVPIHSFSSFPVSLSAINNSHVSESSSSDSSSNFLLEYDFYRDSCPHAEHIVRSTLHLLYKTNPALVPALIRLVFHDCFIQVHFSLERFTSNDSLKGFDVIETIKAKLEEACPGVVSCADILVLAARDSVVLAGGPFYPLNPGRRDGSNSFADIATDELPSPYADLTQTRASFKSRGFDEREMVTLLGAHSIGVIPCKFFENCLYNFSGTNEPDPSLDTQFLNVLRSKCNETDALSTSASAYSSHASPSSLVEEQQEITTDSGESLSNFGTLYYRRLLQGKGILYEDQQLMEGEKTRYWVQYASNRTLFHQDFALAMMKLSDLRVLTKPMGQIRCSCSKV
14
B7PIM6
3.1.3.48
ACT_SITE 376; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
IWPLVSCFCISTVCSARLEQTDEVPSVQIVTLTKLEDTRPTVSSGDARQQTAPTPATAQPRPGVRPAWLLALGVGAVLLLLLAGLCPLLAWWLQRKPLPSKGDPELWLGPPPAGGDTLPLQCVPTAVQSAGPSPLHRTRGLLERRGSNASLTLDLQRTGNSDKQGSGPYLASRRLTRAQLRSCLSNVAALHSEFWDIPMNHPERAAVPGCGGKNRYRSILPNEHSRVLLGPRGDYINANRLRGFKGARSAYIATQGPLPHTVADFWAMVWQERAPVIVMITNLVEDAKVKCEQYLPEGEPLRFGEIGVAVLRTTPRDGYTLRELALECRGEQRRVAHLWYTAWPDHGTPACPQQLLSLAREAEQLRSETGPLVVHCSAGLGRTGCFVASSIGMQQLEAEGSVDVLATVCALRGDRGGMVQTAEQYEFVHRTLCLFEQQLP
149
A7T3N0
3.2.1.52
ACT_SITE 312; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MRVTQLEICRIACFLISLYATGGNTERFSSGDTLWPLPRELEASGGPLPLSLAFTIQTSSESEILARGITRYLEIITTHLHTAARSRVNGSKELEVLRISVKSDDESLNEGTSYEYSLSFDSGPQATLTALTPYGALYGMETFSQLVVDGSLVYTSVSISDKPSFVHRGLMLDTGRRFFPMDLLYNTLDAMSYVKLNVLHFHLSDLCRFSVESKLFPDLRNNESEIYTQDDVRNLVAYARDRGIRVMPEVEGAAHANGLLGLKNKGLQFCNHSGYTQLYNDPQGNTLKTMKAILSEMVPLFPEQIFHLGLDEVFTDKNCTLQSLQSFELALQEHLLQLGKIPAAWEEALSSTKSVTNRTVIQAWKAEGIKTIVDLKQFAINSLSSHFYLNYMGVTPLQLWTDIAVGLNETEVQYLLGGEMAMWTDNYCYILECAYPLSAKPSAYWMYDPLHDGTFTQSVAGIIWPRAVVGAGSFWNYNSDLSADSAEFNMRYQGQHKRLIERGIISCPVGCSCDELTRCGKPYFK
170
I3LQZ5
2.7.11.1
ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 702; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
MGGAEPRSHQSEQPRSSLSCHPAKQQQFEERGGAAPEASERVVQWELALTDARALCPINDGGSNGSSILLAVGGAARRRRRPSRGRFGCAVLAVPAVGGGGEGASRAARAGKLLVSASEFWSRRIPASGAAAGAVKGWASAVSWVPSEDPAGSGKKKMEEEGGSSGGGAAGTSRDGGAGEEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAFSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSAVAKDLIQHLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQNSERLFQGYSFVAPSILFKRNAAVIDPLQFHVGGERPGGTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCTHKKSNQAYAVKIISRRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDLWSLGVILYTMLSGQVPFQSNDKSLTCTSAVEIMKKIKRGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSD
99
Q7JW03
2.3.2.23
ACT_SITE 87; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
MSSPSAGKRRMDNDVIKLIESKHEVTILGGLNEFHVKFFGPTETPYEGGVWKVRVYLPDNYPFKSPSIGFVNKIYHPNIDESSGTVCLDVINQAWTALYDLSNIFESFLPQLLTYPNPVDPLNRDAAALYLHEPEEYHRKVADYVQRYATEDALRAAQQERESSDSESSMSDYSEDEARDMEL
64
A0A1S4BB73
1.11.1.7
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASFSYLSILVLCILGIVSSGHAQLQLNFYAKSCPKAEKIIKDFVQKQVPKAPNTAAAILRMHFHDCFVRGCDGSVLLNFTSSTGNQTEKQANPNLTLRGFSFIDAVKRLVEAECPGIVSCADIIALVARDAVVVTGGPSWNVPTGRRDGRISNVSEANADIPAPTSNFTRLQQSFGKKGLDLNDLVLLSSAHTIGVSHCSSFSERLYNFTGILGTQDPSLDSEYADNLKSRKCKSINDNTTIVEMDPGSFKTFDLSYYKLLLKRRGLFQSDAALTKRTTTKSFIEQLVEGSLKEFYAEFAKAMEKMGRVEVKTGSAGEIRKQCAFVNS
14
A0A251P8Z4
1.1.1.100
ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
MAATIAFNAVGASGRLSRQLSHPRSSYPLLGRIRLHRVAPTRFSRSSSSSSGSAGIRAQVAAVEQSSAAVAQNVEAPVVIVTGASRGIGKAVALALGKSGCKVLVNYARSSKEAELVSKEIEASGGQALTFGGDVSNEEDVAAMIKTVVDAWGTVDVLVNNAGITRDGLLMRMKTSQWQEVIDLNLTGVFLCTQAAAKVMMKQRKGRIINIASVVGLVGNVGQANYSAAKAGVIGFTKSVAKEYSSRSINVNAVAPGFIASDMTAKLGEDIEKKILGTIPLGRYGQPEEVAGLVEFLALNPAASYITGQVLTIDGGMVM
2
A0A3B6ISQ4
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTRWVPPLGLRFSLPLLLLLLAAAVIAPVHAYGKLKVGFYRQSCPDAEAIVRRIVTMAVEDDLTVTAPLLRLHFHDCFVRGCDGSVLLNSTKNNIAERDAKPNLTLDAFNVIDAIKEKLEEKCPGTVSCADILAVAARDAVSLATKVVTKGEWSEGGSLYEVETGRRDGRVSSAKEAAEELPDSFDEIQKLIKRFKSKGLGLKDLVVLSGAHALGNSHCPSLEKRLRNFTAEDDMDPTLDKAYAATLKQQCTSPDDNVTEVQMVPGRSTTFDSTYYRLVKENKGLFHSDEALLSNGATKMLVYGYMSSEKRFLKDFGVSMVNMGRADVLAGSEGEIRRTCAVLN
14
A0A1U8FSJ6
3.1.1.11
ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MVMEWKEMGILTIMVMLWWSAGNCLKFDSTVAKDGSGKYKTIAAAINAAPKMRTKPYYIHVKRGIYYENVTIPYDKTNIALVGDGMGVTIISASKSSKRFPTPNTATLEVYGSGFIGMLMTIRNTAGAKNGQTAALTTAPFRGYASFFRCRFEGYQDTIFALDYAFFRGCHISGTIDFISGNGRAIFQKCSVEARKPIHGQEIRILAPGADNITSNPGIVLQNCKIYPEPGFNRSDGASFLGWPWKNQGKAVIMSSYINDFIDPKGWLSNPEVTNIYLAEYKNRGRGSNTRGRVKWSKVISGNEASKFTVRNFLQGEKWIPKIIPHNLDHLDGAEDSV
125
B3S8C0
3.1.3.48
ACT_SITE 417; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
MATVLSTETAEIGISSSAVEEEMPVSSVIPSPPATEITITEYPNLPSFLPIYVSIRLAMNLETFEANKQEFKDNIAAYLNDNFNETFSNESVIIMNISRIATTNQRAGNDEVIVNFYITNDFAARSVNPTLTKFIGNWLLKLFQDRNDALLGPAFSGKLLQVSLILSNRVADGVVIAVTLSAFAAAILLIAFLYWRSSQTNSQMDKSVLAERLRSGSALRLEFDEIPTMVSSNAELPANIERKNRFINVVPNKLSRVNLRPILGDVTSEYINANYVRGYLGKPRSYIATQAPLTNTVTDFWRMIWENNVKVILMATALDINGSSQCSQYWPLDDEVGASIKADSFLITLHDRVIYDTYIISTLNLQNNKRESIYIKHYWYTKWPADNFPSDEESTVNLLLNIREELKELDSPLVVHCNNGIGRTGVLLAVDTCMRSYDDCRKVDIKKCVERVREDRGGCVQTFDQYLYIYKGSLRIWKSAAMEEQ
149
F1NWE3
3.1.3.48
ACT_SITE 1157; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"; ACT_SITE 1448; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
MRILPSPGMPALLSLVSLLSVLLMGCVAESPPVFIKKPVDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENIYECVAQNPHGEVTVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSTSNGRIKQLRSGGLQIESSEETDQGKYECVASNSAGVRYSSPANLYVRELREVRRVAPRFSILPVSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTETTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQGRMLSSTTMIIQWEEPVEPNGQIRGYRVYYTMEPDQPVSNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNFRAEAKTETSIVLSWSPPRQEIIVKYELLFKEGDHGREVPRNFEPTTSFTVEGLKPNTEYVFRLAARSALGLGAFTPEVRERTLQSILPKNFKVKMVTKTSVLLSWEFPENYNSPTPYKIQYNGLNVDVDGRTTKKLITNLKPHTFYNFVLMNRGNSMGGLQQNVAAWTAANMLSRKPEVTHKPDADGNVVVILPDVKSSVAVQAYYIVVVPLRKSRGGQFLNPLGSPEEMDLEELIQDIARLRRRSLRHSRQLDFPKPYIAARFRSLPNHFVLGDMKHYDNFENRALEPGQRYVIFILAVLQEPEATFAASPFSDPIQLDNPDPQPIIDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKRKDSEPRTKCLLNNAEITPHHPKDPVEMRRINFQTPDSGLSSPLSDPEFDFESMLSHPPIPVSELAEHTEHLKANDNLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILLPIEGIVGSDYINANYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTKLEEKSRIKCDQYWPGRGTDTYGMIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVACGNTEVPARNLYTYIQKLAQIEVGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
149
A0A3B6SV66
3.2.1.14
ACT_SITE 145; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MRGLKMVAMLAMAAMVIGTVRAAQCGSKAGGATCPNCLCCSRYGWCGSTPEYCGDGCQSQFSGCGGGATPVSPNPTVGGVSSVISRSLFNQMLLHRNDPGCHARGFYTYDAFIAAVTAFPGFGTTGDTATRKREVAAFLAQTSHETTGEWPTAPNGPYAWGYCFKQEQNPTSNYCTPSTQWPCALGKSYYGRGPIQLSHNYNYGQAGRAIRADLLGNPNLVATNPTVSFKTVIWFWMTAQPPKPSSHAVITGQWKPSATDKAAGRVPGFGVITNIVNGGIECGHGHDNRVADRIGFYKRYCNIFGIGYGGNLDCYKQSPFI
158
A0A9R0KB62
3.2.2.27
ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072"
MKIPGIIHFPTAIISKPSFSLSYSSFSRHYFYRYFPNNTINMAPSSSSKTLIDFFPQTNPKRRKTTDNGVSAAPLPPLSLLNSDNGDCGSGNPSDDTGLLTADQKFRMEFNKSLALSKLNLRICSDKVQNSKAEGGNGYVKLKELLVEESWLVALSEEFEKPYAKSLCKFVEAEICGGKVPIYPPPNLIFNALNSTSFDKVKAVILGQDPYHGPGQAMGLSFSVPKGIKIPSSLGNIFKELKQDLGCSIPSHGNLERWAVQGVLLLNTVLTVRNHQANSHAKKGWEQLTDAVIRNISEKRKGVVFILWGNCAQEKVRLIDESKHHILKSAHPSGLSAHRGFFGCRHFSRTNQILEQNGELPIDWQV
173
A0A452E9Y6
1.11.1.7
ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
MLVCLHLQVFLASVALFEVAASDTIAQAASTTTISDAVSKVKTQVNKAFLDSRTRLKTALSSEAPTTRQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQNKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQAVLKNKILAKKLLDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHVTKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN
14
A0A9K3JXS4
3.1.1.11
ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MNTKRSILFWLSVTAIVLLSIYTKNPNIITSISLQSFKITSIKSVFDQSGSIHEFISFINQFLVRLYRLLVPCDESKWKSPLIAKYGVALTLTVDQKGCGKFTSLQKAVDAVPANSPKPTLIIVDAGQYREKVNVQKTKSNLIIQGKGFTNTFIIWHDTAAKSNGTVYSYSVGVFAPKFIAHDISFKNEAPLPSPGAIGGQAVAFRISGDQAAFYNCGFYGFQDTLFDDAGRHYFQNCFIEGTIDFIFGNGRSLYENCILNSVASGPGINGAIAAHQRASLQDKTGFSFVNCKIQGQGKIWLGRAWGVYSTTVYIRTFMPAIVAPEGWNDWKDPSRDQKVVFGEHACSGPGADFKGRVKFAKQLSVADATPYMNTGYIDGNTWLHP
125
A0A1S3Y0Y5
3.1.1.11
ACT_SITE 380; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASHFSLPFLSFFLFVSLVSSSISQPPSPSPSPSPNIPIEIQGACKASRDPPTCEASILTDPSNLTPVQIILSALAVSSQNLTNAQSMVKNLLDTSAGNVNLTVAAKNCLLGFNYSAYRYNLTAAALPRGEIKDARAWMSAALGYQIGCSSNLLKVNETIQVAETLEVMNTLINFTTNALWMTVSYDIHGNDTGLWGPPKTERDGFWEPGSGSGFEFKGVVPSGLNPNVTVCKEGVCDYKMVQEAVNATPDNLGPWKFVIWIKAGLYDEIVRVPLEKRNVVFLGDGMGKTVITGSLSVGLVPGMTTYESATVGVSGDGFMASGLTIQNTAGIGAGQAVAFRSDSDLSIIQYCEFLGNQDTLYTQSLRQYYKSCRVQGSVDFIFGNAAAIFQDCDILVAPRLLNPEKGEKNAVTAHGRLDPGQSTGYVFQNCSINGTEEYMTLYHSNPKVHKTFLGRPWKEYSRTVFINSNLDVLINSEGWMPWNGEFALATLYYGEFNNSGAGANITGRVTWSNQIPAERVNSYSIENFIQGDKWIPPSSC
125
O22833
2.7.11.1
ACT_SITE 460; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MSRTIGSRVIFLILALFCCTENSRGKLVMQGSAGFFKGYRTLTSTKKHAYGQAFEDEIVPFKNSANDTVTSFSVTFFFAIAPEDKHKGAHGMAFVISPTRGITGASADQYLGIFNKANNGDSSNHVIAVELDINKDEEFGDINDNHVGININGMRSIKFAPAGYYDQEGQFKDLSLISGSLLRVTILYSQMEKQLNVTLSSPEEAYYPNKPLLSLNQDLSPYILENMYVGFSASTGSVRAMHYMLSWFVHGGVDVPNLDLGIPTFPPYPKEKSLVYRIVLVTSLALVLFVALVASALSIFFYRRHKKVKEVLEEWEIQCGPHRFAYKELFKATKGFKQLLGKGGFGQVFKGTLPGSDAEIAVKRISHDSKQGMQEFLAEISTIGRLRHQNLVRLQGYCRYKEELYLVYDFMPNGSLDKYLYHRANQEQLTWNQRFKIIKDIASALCYLHHEWVQVVIHRDIKPANVLIDHQMNARLGDFGLAKLYDQGYDPQTSRVAGTFWYIAPELIRSGRATTGTDVYAFGLFMLEVSCGRRLIERRTASDEVVLAEWTLKCWENGDILEAVNDGIRHEDNREQLELVLKLGVLCSHQAVAIRPDMSKVVQILGGDLQLPDNLLDIVKAEKVRMWSETSESVLGVLTSQGSIGTLTLTEPFTSRGR
99
Q815K8
4.2.1.11
ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 340; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"
MSTIIDVYAREVLDSRGNPTVEVEVYTESGAFGRAIVPSGASTGEHEAVELRDGDKSRYLGKGVVNAVNNVNEIIAPEIAGFDVTDQAGIDRAMIELDGTPNKGKLGANAILGVSMAVAHAAADFVGLPLYRYLGGFNAKQLPTPMMNIINGGSHADNNVDFQEFMILPVGAPTFKESIRMGAEVFHALKAVLHDKGLNTAVGDEGGFAPNLGSNREALEVIIEAIEKAGYKAGENVFLGMDVASSEFYNKETGKYDLAGEGRTGLTSAEMVDFYEELCKDFPIISIEDGLDENDWDGHKLLTERIGDKVQLVGDDLFVTNTQKLAEGIEKGISNSILIKVNQIGTLTETFEAIEMAKRAGYTAVVSHRSGETEDATIADIAVATNAGQIKTGSMSRTDRIAKYNQLLRIEDELGEVAVYDGVKSFYNIKR
200
Q9SCZ4
2.7.11.1
ACT_SITE 661; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKITEGRFRLSLLLLLLLISAATLISAADYSPTEKILLNCGGGASNLTDTDNRIWISDVKSKFLSSSSEDSKTSPALTQDPSVPEVPYMTARVFRSPFTYTFPVASGRKFVRLYFYPNSYDGLNATNSLFSVSFGPYTLLKNFSASQTAEALTYAFIIKEFVVNVEGGTLNMTFTPESAPSNAYAFVNGIEVTSMPDMYSSTDGTLTMVGSSGSVTIDNSTALENVYRLNVGGNDISPSADTGLYRSWYDDQPYIFGAGLGIPETADPNMTIKYPTGTPTYVAPVDVYSTARSMGPTAQINLNYNLTWIFSIDSGFTYLVRLHFCEVSSNITKINQRVFTIYLNNQTAEPEADVIAWTSSNGVPFHKDYVVNPPEGNGQQDLWLALHPNPVNKPEYYDSLLNGVEIFKMNTSDGNLAGTNPIPGPQVTADPSKVLRPTTRKSKSNTAIIAGAASGAVVLALIIGFCVFGAYRRRKRGDYQPASDATSGWLPLSLYGNSHSAGSAKTNTTGSYASSLPSNLCRHFSFAEIKAATKNFDESRVLGVGGFGKVYRGEIDGGTTKVAIKRGNPMSEQGVHEFQTEIEMLSKLRHRHLVSLIGYCEENCEMILVYDYMAHGTMREHLYKTQNPSLPWKQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPTLDHTHVSTVVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEALCARPALNPTLAKEQVSLAEWAPYCYKKGMLDQIVDPYLKGKITPECFKKFAETAMKCVLDQGIERPSMGDVLWNLEFALQLQESAEENGKGVCGDMDMDEIKYDDGNCKGKNDKSSDVYEGNVTDSRSSGIDMSIGGRSLASEDSDGLTPSAVFSQIMNPKGR
99
Q9KG76
3.2.1.39
ACT_SITE 466; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000305|PubMed:28781080"; ACT_SITE 542; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000305|PubMed:28781080"; ACT_SITE 546; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"
MKGKNVQLLFALVVIILLFPTGASASPHAVSVGKGSYATEFPEIDFGGINDPGFRDQQGEPPATIYRSDRVTGPMQTNSWWGSLAVDRFSMNQYPHPFSVRHRAEGLHVFYDAPHNMVVHENREAGTWHIHGAIGTDFTIKHSGTANFEQAVVDDYNDWYVRGLLENGAHQMAITYGVGSPYIFVEYEDGSAVLDFDIAPDVWEMNGHVIGFSTHDHKHYAAFAPPGQNWSGIGSKTLTNNADYIAIAKLPEKDGNMLAKFEQYAYSVVRDAVADWTYDEATGTVTTTFEVTTEAKVQGAPDGTIFALYPHQYRHLASSSENQLLQNYQYEIIRGTMIGLEGKRFTTELTYPGVLPSLPDLGDYDRERLIGYLHDATSDYPTGSDTYELGKYIGKLATLAPIADQMGEYELAEQFRGELKDILEDWLQATNASGQLKGKNLFYYNENWGTILGYHAAHSSATRINDHHFHYGYFVKAAAEIARADQEWAKSENWGGMIDLLIRDFMADRDDDLFPYLRMFDPYSGNSWADGLATFDAGNNQESSSEAMHAWTNVILWAEATGNKALRDRAIYLYTTEMSAINEYFFDVHQEIFPEEYGPEIVTINWGGKMDHATWWNSGKVEKYAINWLPFHGGSLYLGHHPDYVDRAYEELRRDIGSTDWNLWSNLVWMYRAFTNPDDALQQMEASIDDYGLFDPGNEKIIERGSTKAQTYHWIHNLAELGRVDPTVTANHPIYAVFNKNGNRTYIVYNFSDSPITVQFSDGHSIQVEPHSFNIGNGDGPTNPDPSEPDLKNPYERIQAEAYDAMSGIQTEGTDDDGGGDNIGWINDGDWVKYERVHFERDASSIEVRVASDTPGGRIEIRTGSPTGTLLGDVQVPNTGGWQQWQTVTGNVQIQPGTYDVYLVFKGSPEYDLMNVNWFVFRANGQGNGDSHTHPDYTAGIRGITGNEVTIFFAPTTEARYVDVHLKVNNGQQLNYRMTERNGEWERVVENLSSGDVLEYSFTYEKLGPQYTTEWFTYSR
167
A0A5F7ZIA6
2.7.10.1
ACT_SITE 980; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
MAESPASAFRDSLRKSVRTAAGNPGVPELGGTHPGLREEREKVKLGVATPRLVGMQLEGASWERACSQSQEEEEVEEEGCLRKYKNEVVELRFPSIGTGETRGAAWAAVRPFPRGSFRRRAPGPHPSPHPAPHALPAGSSRSHGAGAAVSTMELAAWYRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDLLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPVCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITGYLYISAWPDSLPDLSVLQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQSCPINCTHSPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGTGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPRAPSEGTGSDVFDGDLGMGAAKGLQSLPAHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPGMESSLSGETDGRGRGDPQPRVHCGGRGSGSDTGVPSPNRSSSLGLSEYVNQPDVRPQPPSPQEGPLSPARPTGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRGGAAPQPHLPPAFSPAFDNLYYWDQDPSERGAPPSTFKGTPTAENPEYLGLDVPV
97
Q89ZG8
2.7.7.7
ACT_SITE 95; /evidence="ECO:0000256|HAMAP-Rule:MF_01113"
MDAFYASVEQRDHPELRGKPLAVGHAEERGVVAAASYEARRYGVRSAMSSQKAKRLCPQLIFVSGRMDVYKSVSRQIHEIFHEYTDIIEPLSLDEAFLDVTENKKGISLAVDIAKEIKLRIREQLNLVASAGVSYNKFLAKIASDYRKPDGLCTIHPDQALDFIAGLPIESFWGVGPVTAKKMHLLGIHNGLQLRKCSLEMLTAHFGKVGALYYECSRGIDERPVEAVRIRKSIGCERTLERDISVHSSVIIELYHVAVELIERLQRKEFKGNTLTLKIKFHDFSQITRSITQSQELYTLDRILPLAKELLKSVEYEQHPIRLIGLSVSNPKEEADEQHGVWEQLSFEFSDWE
121
Q89H18
3.2.1.21
ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 431; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MSRPGRRNSASDLPQSSLLKPPATGHCAAAPASSRGQHHMSDKVSRRQFAALAGLSAAAIANPLDGADAKPAAAASRDSGFPEGFLWGTATSSYQVEGAVNEGGRGASIWDRFVRIPGKIEDGSTGDRANEHYHRYKEDIALIKELGCKAYRFSIAWPRVFPDGDGKPNPGGLDFYNRLVDELLKNGIEPWMTLYHWDLPQSLQDRFGGWRSTETCKIFGDYAAYVAERLTDRVKNVFTLNESGRFVQFGYGLGIDAPGVTLPQGEVNQVRHNSALAHGLAVQAVRAHGRRGTRVGPAENIDVCVPAIDTPEHVRAAEIALREMNAGYLNVIMTGSYTEAFLKYAGANAPKYTDAELKIISSPVDFLGLNIYAPQNYVVPSDQGAGFMPLPIPKSFPHMNSDWLRVAPETIYWVPKLAAKIWKTDAIYISENGTSGDDVVTPDGKIYDTDRIMYLRNYLAQLQRATAEGVPVRGYFLWSLMDNFEWVFGLSKRFGLYHVNFDTQVRTPKLSASYYRNVIARNAAGV
161
Q9HFU4
5.3.1.8
ACT_SITE 310; /evidence="ECO:0000250"
MSPSVFKISPGINSYDWGKKGSASLAAQLATTSIPDFSIDEDKAYAELWMGTHPNNPSRLSDNTLLSEHLKSHPELIGSSVSSKFEDCKDGSLPFLFKVLSIGTALSIQAHPDKPLAKKLFDEKPDVYKDPNHKPEMAIALTPFLAFLNFLPLSVLLLHLLTVPELQEFVDSSLTESLASSLGLPTSQPPDTSLFKPTESPATAEQKDILKQIFAALMSADKKLVEEAISKLIKRYQAKRDIKENEKSLVDLALRLNDQYPGDVGVLCVFLLNVVELKRGEAAFLGANEPHAYIEGDIIECMATSDNVVRAGLTPKLRDVDTLVSMLTYEAAPGNKQLLQPTPFQKGDDTTKLYDPPIAEFSVLRTELSKGMKTSHRPVEGPSLCVITEGEGVVRNGNDRSEFVRGDVIFVGAGKEVEWEAIKGLEMFRAYVEA
214
A0A061EPH4
3.1.1.11
ACT_SITE 266; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MWTTKEFVGGPLKIEDPFPTNFSSQLMNIQFYLPTNCIPKKSSETSLKSFANLQKASSQLNLFTNMSWRFFRPMHLAFAAIVAVAICFPGCANGMSAERVIDSPLLTEKISTNRTIKVDLNGNGDFTSVQEAINSVPKGNSQWVIIHLRKGVYREKVHVPKDKPYIFLRGNGRGRTAIAWSQSSVDNKASATFTVEAKHFIAFGISFKNEAPTGIAYTSQNQSVAAFVGADMVAFYHCAFFSTHNTLFDYKGRHYYDNCYIQGSIDFIFGRGRSLFHNCEIFVLQDKRIKIRGSITAQNRGSPQDNSGFVFVEGKVYGIGGVYLGRAKGAYSTVVFAKTYLSRTIVPHGWTDWSYHGGSDHLFHAEYDCRGPGADTSERGHWAKQLTEKEAAYWTSIDFINGKDWLPVWL
125
Q21017
2.7.11.1
ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAAPRRRMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFATYELLADKVKKGTLEGTGEEFPRRGSRGSILSGKANVDEQPLTPTISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLCASEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIADLSKMLPVPKSERRASAGETLLPTNFDLTQHLANLPAPPISFPTVEEEGKSYLSKYGGKRNTVHCLGNQLGGGIQNPIPRYQRTPYTKAPPAERRSSWASPSLSAQQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSSLACPQISITDEYNRQHNIAPSASSFDPVSIFQKNAQEVVFGQRPATAIGFSSTSFSGMSTPEQTTRSIDDRVRSIVCTLPFTEVIDELKASLNILKIPFSESHEMVYEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIINNDSPTSEYLCDQLICRLRMIDPSWSSE
99
F1RGV0
2.7.11.25
ACT_SITE 272; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1"
MALPGAEGAVDRPGSPARGAPAASSSSSSASSGGSASASASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWTGQVQRRLGIFPANYVAPCRPAALPASPPARLPPPRPGSPVHVDFELLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLRQPHLCLVLEFARGGALNRALAAANAAPDPSAPGPRRPRRIPPHVLVNWAVQIAQGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDFCNKTLKITDFGLAREWHRTTRMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKDCWQQDPHVRPSFASILEQLTAIERAVKTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELMRAALQQKSQEELLRRREQQLAEREIDVLERELNILIFQLNQEKPNVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTVIPRLRAIQLTSDESNKTWGRNTVCRQEEFEDVKRNFKKKGCTWGPNSIQMKERADCKERIRPLSDGNSPWSTVLIKNQKTVPLASLFVDQPGVCEETKPASDGLEHRKPKQIKSLSQAYVDLPLWKDGQRENPVEVESWEEGVPVSPATGTPQGTPPNSLSRPSQRKKLESALYGCTVLLASVALGLDIRELAKAQATEEPPAKEEKKKREGIFQWAPKPRSGASPAMRLPTSGEGASSTPSPTLPSAVGLLSMPSLSTKCLLQTDGEDAFESSTHTPGDPDMPTLALCPGFGGRAEEPAPVPGLEVGRSVWGDLPPSFVEQAHGDVPSSASKERAAHHRRTMSDGRAFQPPAGAALVSTPRASELPPAWVWGMPPSWSGPHSDLPREVPPEKQRAIHVVPLPRPSSQRSGAGASPAFPPLGTGSQPAQAGPVVGGPAPAPDQSLDAKERTRAHVPCLLDADVEGQSRDCTVPLCRMGSRAGPPSLYQLEKEFLS
105
Q0V2H0
3.1.3.16
ACT_SITE 282; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1"
MGNPQEEATALKNKGNDAFKNQDWPAALDFYTKAIELWDKEPSFYTNRAQANIKLESYGYAVADADKAIELDPNNVKAYYRRASANTSMLKHREALRDWKLVIKKAPNDANAKLRMHECEKIIKRDAFLKAIEVEDAPSAAEGLDIEHMALERNYDGPKLEGKMTLEFIEDMIERFKTGKKIAKKYAFQIILAVMDIVKNEPTMVEHKVEEGCEITVCGDTHGQYFDLLNIFKLAGKPSEKNHFLFNGDFVDRGSWSTEIALLLYAYKWLYPDKFFLNRGNHETDDMNRMYGFEGECRAKYNERMFKIFSESFSMLPLATLIGDKYFVLHGGLFSDDKVTLDDVRKLNRFKQRQPGQAGLMMEMLWTDPQTAPGRGPSKRGVGLQFGPDVTKRFCENNGLEAIIRSHEVRMEGYEVEHDGRCITVFSAPNYCDSTNNKGAFIKIGPEYKLKYTKFDAVPHPDVKPMAYASNGLM
144
A0A1D5QL11
2.7.10.1
ACT_SITE 768; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MINCDYLCCHKKRQEQRWHRRTMAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIVLVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
97
Q058B4
2.2.1.2
ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MNQLEYLKKYTTVVVDSGDINYIKKYQPNDATTNPTLILKSVLSNKYNYIIDNSIQYAKDIGGNKLTQVKNASDMISVGFGIEILKYIPGYISTEIDARLSFNTKKCVSKAIKLIKLYNNNGIDTSRVLIKLAATWECIEAARQLKKIGILCNLTLLFSFAQARACADADVFLISPFVGRIYDWYQKFNLNSPYCSNTDPGVIALKKIFFYYKKYGYKTIIMGASFRKLEQIQELVGCDRITISLDLLKQLSMKKDILIKKLDVKKITKVNTKPNALSESEFRFLHNEDAMAVEKLSEGIRQFSSDQQELENFLFDKL
52
Q6DBX4
2.7.11.1
ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEARGLACESSNSAVKAPSIEDFVLVKPISRGAFGKVYLARKKCNSKLYAIKVVKKAEMVDKNMTEQMRAERDALALSKSPFIVHLFYSLQTATKVYLVMEYLIGGDVKSLLHIYGYFDEDMSLKYISEVALALDYLHRHSIIHRDLKPDNMLISNEGHIKLTDFGLSKVKLDRELNLMDILTTPSLVKPTKDYFRTPGQVLSLISSLGLNTPVIEGKRHSSTVLGSPMSCGKVKQRNRSLGSPLMKRRAEYMNSPVCTSRALASNSVFSPVLLARSLTPRLLKSGKRLDTMSVGSTHSCMLPSTTDSENCVSPMWEDEQNLHDVENIPQLNGREVDNRKSRNVPLTPVEKRKTLPARAQDHRPVFTPLNNQVTNSRNIKPDLSAKRLQFGATDNSATPLEKTVPHQSVGNGLIKPEPLKELKSSVKRAFEEVEKSPEQAEILFKKNDAAYERSFQIPEKTSRAHTGLTGIFSIVGLDDVKSAPKCQQFNERTGPKQSSPIAVAKNLFCELEDQGEEGGKAEPNSSSSTSPGDERNIRRSLSLESDVSAHEMSLVANTPQKLSDAKQEVLSSSFEELDENEISAVTPMARPTVATPKHSSAKQRRGECERSLLDHPHGLSDSMIKSPGFLKPKNVVAFRSYCSSINRSCTSHLSLASFDAMEMSASASFHNAVTPVQKKRPSLSNSLYQTPQQMVVSHTPYRTPKSVRRGPERVEGAPILGTPDYLAPELLLGKPHDFMVDWWALGVCLFEFLTGVPPFNDETPQLVFQNILNRDIPWPDGEEELTLNSRNAIEILLTMDTLKRAGLKELKDHPFFDGVDWENLHHQTMPFIPQPDNETDTSYFEARNTAQHLTVSGFSL
99
A8N936
6.5.1.1
ACT_SITE 291; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135"
MMQPTPAPSSAPGSPQRTQAEPEMETPSYPQPPQNVGTAPFSVLVKLFEKLATERKQERRRKLLDAWFRHWRREKGFDLYPVLRLLLPQKDRDRAVYGLKEKNLAKTYIKLIPLGMRDPDAIRLLNWKKPTERDKSSGDFPQVLCEVVSKRSSVIEGTLTIDELNEILDDIAKNMGKSDVQSKILRRIYNNSTADEQRWIIRIILKDMNISVKETTVFAVFHPDAQDLYNTCSDLKKVAWELWDPSRRLNAKDKEIQIFHAFAPMLCKRPTRKIEETVKAMGGSKFIIEEKLDGERMQLHKRGNEYFYCSRKGKDYTYLYGKHIGAGSLTPFIDSAFDSRIDDIILDGEMLVWDPVSERNLPFGTLKTAALDRSKKENNPRPCFKVFDLLYLNGMSLLDKTVKFRKNNLRHCIKPIPGRIEFVEEYQGETANDIRKRMEQVMENRGEGLVIKHPKAKYILNGRNTDWIKVKPEYMDNMGETVDVLVVAGNYGSGKRGGGVSTLICAVMDDRRPDSDDEPKYSSFVRIGTGLSFADYVWVRSKPWKVWDPKNPPEFLQTAKKGQEDKGDVYLEPEDSFILKVKAAEITPSDQYHMGFTMRFPRALAIRDDLSIADCMTATEVFESLKSERKRKMEDDAGITTKKRKTTVKKVALLPEYSGPNLKKVAVKTDIFNGMKFVVFSDPKSRTGEADKKELMKTIHANGGTCSQIVNKNSEAIVIYGGSITPYDLKLVIDKGIHDVIKPSWITDSVTLGEPAPFKKKYFFHATEERKYADEYNEDDGEEEGAVPSADEQERDVKSGTVEPGSETEDEDEEQAPEIKEEQDGELHEWLKVDDRKSPALPAHDEEDSVTEDDSDNADVADEEEPDLDDWFQVKGETEDEGAGALATASRHRETTPDVDGDVKMGESEEAMDYDPDVIFKHLCFYLDSPANAQRHGMATRPKYEAAITKSFEEVEKLIKDNGGKIVDLDEPKLTHVVLDKRDDSRRVELMKRTSKPRRRHLVLSDYIEACIDEGTLLDEEGESF
254
A0A059CEW5
6.3.4.4
ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 117; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 217; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MYNLSSSISTSTRPGGAASPRDRLLLSGGGGGGGGGRRRAAFVVCSVKPPSATSSAATLAAPGQGKTEAAGRIAGLSQVSGVLGSQWGDEGKGKLVDILAQHFDVVARCQGGANAGHTIYNAEGKKFALHLVPSGILNEDTLCVIGNGVVVHLPGLFEEIDGLEAKGVSCKGRILLSDRSHLLFDFHQEVDGLREAELADSFIGTTKRGIGPCYSSKVIRNGIRVGDLRHMDTFPEKLDLLLSDAASRFPGFKYGPGMLEEEVERYKRFAERLEPFIADTVHVVNESILQKKKVLVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRILGDLIGVVKAYTSRVGSGPFPTELFGNEGDMLRSAGHEFGTTTGRPRRCGWLDIVALKYCCQINGFSSLNLTKLDVLSYLPEIHLGVAYTLPDGTPIKSFPGDLDLLEQLKVEYEVLPGWKCDISSIRNYSDLPKAAQQYVERVEELVGVPIHYIGVGPGRDALIFK
253
P41571
1.1.1.49
ACT_SITE 276; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P11411"
MATQHFTNGSATDDGETALEHIIKSLETPTMKCEGTHFDSHVPHTFVIFGASGDLAKKKIYPTLWWLYRDNLLPKSTKFCGYARSKLTIEELRAKCHQYMKVQPDEQAKYEEFWQNHDYAAGSYDQRSDFVALKERLSSLESCNCSCNRIFYLALPPSVFERVTVNIKDICLAERGWNRVIIEKPFGRDDVTSKKLSDHLASLFHEDQLYRIDHYLGKEMVQNLMTIRFANKILNSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPTSCQPDDIRDEKVKVLKSIPALTLDDMVLGQYVGNPNGVGEQREGYLDDPTVSNDSNTPTYAQGVLRINNERWDGVPFILRCGKALDERKAVVRIQYRDVPGDIFEGNSKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKNSYLPDAYERLILDVFCGSQMHFVRSDELSEAWRIFTPVLNEIENNKVKPIPYVFGSRGPKEADQKTSENNFKYYGSYKWIGKK
6
Q9R0A5
2.7.11.1
ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQIIREYGEQILDEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCSHTELESTGTTPAGNALERAARGNPESGNPQEHGRHTSPASPHRPWWERHGPSSNVEALEKASILTSSFTAEDDRGGSVIKYEENARRQWVREPPEALLSMLKDADLSQAFQTYTIYRPGAEGFLKGPLSEDTASDSVDGDLDSVMLDPERFEPRLDEEDTDFEEDNENPDWVSELKKHVGYGDGPGGQLLGERA
99
M5X1V1
1.1.1.205
ACT_SITE 320; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 416; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"
MSSSIFEDGFSSDRLFNQGYSYTYDDVIFLPHYIDFPTDSVHLATRLSRRVPLSIPCVSSPMDTVTEAHMAISMAALGGIGIIHSNTTPSEQAHMVKAVKSRRVPVLSNPVFKSPSDRIQSDDVFDSSNPYVLVTENGSPSSKLLGYVAGRDWATLGDKEVKIYDYMVNCTDFTVPWSYDLGRIGEHMEEKRRDVVATVRDDEVVDVVAKEEVERIKGYPKLGVGTVGPNGAWRVGAAIGTRETDKERLEGLVKAGVDVVVLDSSQGNSIYQIEMIKYVKKTYSNLDVVGGNVVTVSQAQNLIQAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVASIASQSGVPVIADGGISNSGHIVKALVLGASTVMMGSYLAGSTEAPGAYEYQNGHRIKKYRGMGSLEAMTKGSDQRYLGDTAKLKIAQGVVGAVADKGSVLKFIPYTIQAVKQGFQDLGASSLQSGHDLLRTSVLRLEVRTGAAQVEGGVHGLVSYEKKSF
3
Q6CE12
2.1.1.33
ACT_SITE 191; /evidence="ECO:0000255|HAMAP-Rule:MF_03055"
MLKRDQSEMDIEAETANMGKEEKESFVHKRQKYRQEQEEKRLAAKKGVSFEQPEDGEIKLPKKRYYRQRAHSNPFSDHQLEYPESPADMDWDVLYPNRKEGQKVEVADIGCGFGGLLVALSPQLPNQLILGMEIRVQVTNYVEDRIVALRHQNKETDGYQNISVLRGNAMKFLPNFFEKGQLSKIFFCFPDPHFKQRKHKARIVTTTLCSEYAYVVRPGGIVYTITDVKDLHEWMVKHLAAHPLFERLTKEEEDADPCVATMLVETEEGKKVARNEGDKFVACFRRKENPEW
45
M4DEH4
1.11.1.7
ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKAAVVSVLILLVIFVAWPVSADRKDLPGAGGYGGDEDDDNDTKSWFPLDNQLSLSYYDRICPDFEKIVATKVREWTKKDSSLGPALLRLLFHDCGVTGCDASVLLDHEGSERRSPASKTLRGFELIDDIKSEIEKACPGLVSCADILTAASRDATFQLGGPYWPNAYGRRDSTDSYARDVEKVPSGRRDITALLETFQSYGLNVLDLVVLSGAHTIGKAYCGTIQSRLYNFNATYGTDPSIDSKYADFLRRKCRVASETVYLDAATPVKFDNQYYINLQKNMGVLTTDQELVKDPRTAPLVKAFAEQPPHMFRQQFAVSMVKLANVGVITGEDRIGVIRKVCSKSNSRPY
14
A9UUG1
3.4.19.12
ACT_SITE 12; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 116; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MVYHERQESALCAQHALNSLLQGSFFSASDLGEIACQLDEEERSRYAEAGLDSRDLLNSFSGSQNCDDSGFFSSMTIERALQVWSLELIPRQSQRAVEAVRQPEQEQGFICNFDSHWLTLRRLSGQWWNLDSTLEQPEPMSDTYLGLYLQQLEQDGLHPPTHQLVLNPALQATPSLWSEARFQQVQGPHNRWIDKQYGMPGWLQYSAPMLKTLEAQALGEMSLLHDLNCG
175
E1BMG4
2.7.11.13
ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETDSFFALHHRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCQQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDSEHIFREGPVEIGLPCSIKGEAKPPYVPGPGKKEPQGISWESPLEEMEKVCHRPEPEPNKERGSLRMKLKIEDFTLHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLCRATDLKLDNILLDKDGHIKIADFGMCKENMLGDARTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLVGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMEKLIS
100
Q89L91
3.2.1.21
ACT_SITE 171; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 351; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MPTTQLPNTASLRPGFIWGVSTSSFQIEGATKEDGRGLSIWDIYCRSGEIKNHDTGDVACDHYHRYREDVGLMKTLGVQAYRFSVAWPRVLPLGLGSANEAGVSFYDRLIDELVAAGIEPWLCLYHWDLPQALEERGGWLNRESAAWFADYVTLIAARFGDRVKRFATFNEPSIFSLFSRSLGKREHSSEDKFHRMIHNVNLAHGAAVDVLRANVIGASIGCIHNRQPCRPSSASEADEAAAARLDVYWNAAFPDPQCRGEYPPSMRAAIEPHMQPGDLTRICRPLDWFGLNHYSPVYVKARADSMLGYDFGDKPASVPLTPIGWPIDPEAFSETLQAVRTRYGLPIYVLENGYGDSGQPDQTGAVIDPGRIEFLKAYINAMNNAAAHGVDVRGYFVWSLLDNFEWASGYSIRFGLTYVDYASLRRIPKSSFGWYAGLIRAVQP
161
Q8DPM2
5.6.2.2
ACT_SITE 120; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897"
MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQVLSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA
222
Q8BY87
3.4.19.12
ACT_SITE 197; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 503; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSERITLNLPASTPVRKLFEDVANKVGYINGTFDLTRENGVTTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLEDSNNVDDSVHDRFIGPLPREGSVASTNDYVSQNYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSSGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVTEFKQLISKATHLPADSMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERVKGPAGNLKSVDAILEESTEKLKSLSLQQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGDMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPAEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD
175
A0A7M7N7J8
2.7.11.23
ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
MARNMLAGDRSKLYENIDFLGEGQFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVIGLLDCFGQRSNISLVFDFMETDLEVIIKDSSVVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYFYTKPAPTPGHLLPRPGMVAAAANGKQQPKLGSKRKMADDIGTGSTAKKLVF
103
A0A8V0YGR1
2.7.10.1
ACT_SITE 865; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000631-1"
MRSVRGAAGLLLLCGASFGLYFPRKEYSENVYIDQPAGAPLLRIHALRDSHGETAHFHLCQNLIISRARSHENHWFQIREKMGLLYLSKSLDREDFNMLSVGNWMPLSKVMLYVFLSSHPFQEKECDSATRTTVVLSLINATAPACSSLSARQLCFTEMDLSFHIKENKPPGTFHQLQLPSVHHLCQNLSITYKLLAAEGLPFRYNENTTGVSVTQRLDREERERYELIAKCTVREGFREMEVEVPFLVNVLDEDDSPPFLPNGTDTADAVVEFNRKEGTVLATLTVYDADTTPIYPLESSRKKYTGTIITDDPWINETFRVEHIFDEIHFSPNGSQVRGTQHEYKLVLNKSISVTEHRSFQLDVLVNDTEFNGPEKSVMLHFNVSILPVSIQFPNTTYRFTVNRNAQRFAQIGKICIENCMKFRGVNITYKLLSPNVSCYAVGILQGREDKYGSLYVNDSSVLLRPECKEIQYTVQATDKQSRKHTKTLFTVVLEGTLFKKEEDCPDSCAMSKHLAECEECGGLGVLTGRCQWRQGSGKGITTNYSTCTPSIKTCPDGTCDVVESKDPAICPQDCTNGNIIGGHGKGTGNLGIKSGHGICYCFPRQNCYCEKDDIKEQFCDEVCKTVIAGAVLLSFIISVLLSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPISYSSTNVRRPSLDSMENQVSVDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLYLIVEYAKYGSLRSFLRESRKVGPSYVGSDGNRNSSYLDNPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMERPENCSEEMYNLMLRCWKQEPDKRPTFAEISKELEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNNAPLPRTLPSTWIENKLYGMSYPNWPEESPVPLTRFDGTNSVFSRYANDSVYANWMVSHSAAKFVDKFDS
97
A0A803T594
2.3.2.26
ACT_SITE 1999; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MSNRPNNSPGGSLRRSQRNTVGAQPQDDAVGGRSHLGQAKHKAQSPSESRKSISKAPKVQSNTTSEQPKGHFSKRGCSSSAIIIPQQEALETESTLERQKPGQVAKKDNPRGVKRSASPDYNQTNSPSPAKKTKALQHADSSSDLERNKPQTKSKKRHLHQEQESKSSQLPSTSKAHTRKGGATGSSRSQKRKKTETSSIVKSRPESAGSEERPAKVTKLASKSASSAKAGCSTITDSSSSASTSSSSSVVASASSGVPQGARVKQGKDQSKARRSRSASSPSPRRSSRDKEQNKIGGSSKFDWAARFSPKVTLPKTKLSLPGSSKPEASKPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPDNNQDGVNSSAARADEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQATDESQQLQSVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNIQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNTQNTDGAIWQWRDDRGLWHPYNRIDSRIIEAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANTNTSGQPESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKNLAESETLLTSPPKACTNGSGTLGATTTVSTGTATAASNAASDLGSPSLQHSREDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTATQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGVECLLEIRSIVSESDVSSFEIQHSGFMKQLLLYLTSNSEKDAVSRDVRLKRFLHVFFSSPLPGEESLGRLEPLENAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGSSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSLQAEEERESTDDESNPLGRAGIWTKTHTIWYKPVREDEDSNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGICPSVSNPLEVYLISSPPENITFEDPSLDAVILLRVLHAISRYWYYLYDNASCKEIIPTSEFINKLGKSCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLANPKGSQEGTKYIHNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFNIDPVVARSVYHLEEIVRQKKSLEHDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDLPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKTDTWDAKTLMECCRDCSFGFLFEILSSFDSEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS
65
A0A804JS77
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAATSGFAAVFAIASLLCLTIAPTRGALQAGFYKGKCNGTDVEATVKSIVAARFAQDRSIVPALLRLHFHDCFVRGCDASILIDGSGTEKTAPPNLSVRGYDLVDQAKAQLESTCPGVVSCADIIAIATRDAVVLGGGTQYTYVVQTGRRDGNISLASDASANLPGASLSASQAIAAFRAKGLNASDTVLLLGGHTVGITHCSFILNRLYNYNGSGKPDPDMDPAFVAMLKSRCPQTSAVDNSVFLDNGTPSTVDNSYYKQLLAKRGVLKVDQNLAMDAATNGTVKSLASGSLSFPSLFGNAMVKMGSIQVLTGTQGQIRKSCRVVNK
14
O86616
3.2.1.23
ACT_SITE 160; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 236; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
MKRSTLSYTDGTLLRNGRPHRLLAGSLHYFRVHPGHWADRLRRLAALGLNAVDTYVPWNFHERTAGDIRFDGPRDLARFIRLAQEEGLDVVVRPGPYICAEWDNGGLPAWLTGTPGMRLRTSHGPYLEAVDRWFDALVPRIAELQAGRGGPVVAVQIENEYGSYGDDRAYVRHIRDALVARGITELLYTADGPTPLMQDGGALPGELAAATFGSRPDRAAALLRSRRPAEPFFCAEFWNGWFDHWGDKHHVRPAPSAAEDLGGILDEGGSVSLYMAHGGTNFGLWAGANHEGGTIRPTVTSYDSDAPIAENGALTPKFFALRDRLTALGTAATRRPLPADPPLLAPRDLPVLRQAALLDALRATAEPVTAPLPLSFEELSLASGLVLYEAEPLLPPGEHEVTVTGLHDRAQVFADDTPVAVLDRESASFTVTGTGARVRLALLVENQGRINYGPLLGQGKGILGGVRVERRLVHGWTMRPLPLDAWTGRDTARAAAAAPSDGRAGFATAVLPVAEPADAFVALPGFGKGFLWVNDTLLGRYWEIGPQSTLYLPGPLLRPGGNTLTVLELERLGDRVALREGPDLGPSEEYVETFD
163
P43293
2.7.11.1
ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MGGCFSNRIKTDIASSTWLSSKFLSRDGSKGSSTASFSYMPRTEGEILQNANLKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRRAIDKNQPVGEHNLVDWARPYLTNKRRLLRVMDPRLQGQYSLTRALKIAVLALDCISIDAKSRPTMNEIVKTMEELHIQKEASKEQQNPQISIDNIINKSPQAVNYPRPSIM
99
F6HRL7
2.3.2.26
ACT_SITE 816; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MRKFDQNAFVSCNSPPDSHLERHRVVDARSCPSSCSAESARPDSRLQFFVRMISEGNTLVIHANSDDTVESLHHRIQSITGIPVMEQRLIYRGKQLQWEQSLAECSIQNDAGLQLVGRMRSTEHPAAWRVASEMVSTICRLCRGETFRPLKNIKSQLLEFLMLTPKDDTESAAGYLQVFMSSSAPSALVMLYMSPTKSNKETADDTIRQFLNSSRNLLPKSVQIQCVPIVLEFCKLLSRTDHEDPLYLTCRSTLGSLVENVGVVRASRYCHNSKTLIVVKEILPFVSELASSLSKSLISSMESAGSTGNSLNDGRNLIAGHTLANDVRDFTAFLHPVRSVIMEQVSFHGPISIPLGERGSTNPWYGEEIEFLHGIFIDLMTKMDGCLHKMEQCLAGEGGVDHHTVWPQYLAVLKELNSISKLYHGAEEEFWTFMRRRKIAVCSLMIRYAKRSDDHSWLLEHKDVTDFESRRHLAMMMFPEVKEDYEELHEMLIDRSQLLAESFEYIARAERESLHGGLFMEFKNEEATGPGVLREWFFLVCQEIFNPQNALFVACPNDRRRFFPNPASEVDPMHLQYFRFSGRVIALALMHKVQVGVVFDRVFFLQLAGMDISLEDIQDADPLLYTSCKQILDMDAEFMDSDALGLTFVREIEELGSRRVVELCPGGKNIIVNSKNRDEYVYLLIRHRFVTSTSEQVAQFAGGFADILCNQKLQKFFFQSLELEDLDWMLYGSESAICVDDWKAHTEYNGYKETDPQIFWFWKIIGEMSAEQRKILLFFWTSVKYLPVEGFGGLASRLYIYKSSEPCVRLPSSHTCFYRLSFPPYPSMAIMEDRLRIITQEHVGCSFGTW
65