diff --git a/packages/tailwindcss/src/utilities.ts b/packages/tailwindcss/src/utilities.ts
--- a/packages/tailwindcss/src/utilities.ts
+++ b/packages/tailwindcss/src/utilities.ts
@@ -387,6 +387,8 @@ export function createUtilities(theme: Theme) {
       handleNegativeBareValue: ({ value }) => {
         let multiplier = theme.resolve(null, ['--spacing'])
         if (!multiplier) return null
+        if (!isValidSpacingMultiplier(value)) return null
+
         return `calc(${multiplier} * -${value})`
       },
       handle,

diff --git a/packages/tailwindcss/src/utilities.test.ts b/packages/tailwindcss/src/utilities.test.ts
--- a/packages/tailwindcss/src/utilities.test.ts
+++ b/packages/tailwindcss/src/utilities.test.ts
@@ -3861,6 +3861,82 @@ test('translate-x', async () => {
       '-translate-x-[var(--value)]/foo',
     ]),
   ).toEqual('')
+
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --spacing: 0.25rem;
+        }
+        @tailwind utilities;
+      `,
+      ['translate-x-full', '-translate-x-full', 'translate-x-px', '-translate-x-[var(--value)]'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root {
+      --spacing: .25rem;
+    }
+
+    .-translate-x-\\[var\\(--value\\)\\] {
+      --tw-translate-x: calc(var(--value) * -1);
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .-translate-x-full {
+      --tw-translate-x: -100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-x-full {
+      --tw-translate-x: 100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-x-px {
+      --tw-translate-x: 1px;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    @supports (-moz-orient: inline) {
+      @layer base {
+        *, :before, :after, ::backdrop {
+          --tw-translate-x: 0;
+          --tw-translate-y: 0;
+          --tw-translate-z: 0;
+        }
+      }
+    }
+
+    @property --tw-translate-x {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-y {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-z {
+      syntax: "<length>";
+      inherits: false;
+      initial-value: 0;
+    }"
+  `)
+  expect(
+    await run([
+      'perspective',
+      '-perspective',
+      'perspective-potato',
+      'perspective-123',
+      'perspective-normal/foo',
+      'perspective-dramatic/foo',
+      'perspective-none/foo',
+      'perspective-[456px]/foo',
+    ]),
+  ).toEqual('')
 })
 
 test('translate-y', async () => {
@@ -3933,6 +4009,82 @@ test('translate-y', async () => {
       '-translate-y-[var(--value)]/foo',
     ]),
   ).toEqual('')
+
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --spacing: 0.25rem;
+        }
+        @tailwind utilities;
+      `,
+      ['translate-y-full', '-translate-y-full', 'translate-y-px', '-translate-y-[var(--value)]'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root {
+      --spacing: .25rem;
+    }
+
+    .-translate-y-\\[var\\(--value\\)\\] {
+      --tw-translate-y: calc(var(--value) * -1);
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .-translate-y-full {
+      --tw-translate-y: -100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-y-full {
+      --tw-translate-y: 100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-y-px {
+      --tw-translate-y: 1px;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    @supports (-moz-orient: inline) {
+      @layer base {
+        *, :before, :after, ::backdrop {
+          --tw-translate-x: 0;
+          --tw-translate-y: 0;
+          --tw-translate-z: 0;
+        }
+      }
+    }
+
+    @property --tw-translate-x {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-y {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-z {
+      syntax: "<length>";
+      inherits: false;
+      initial-value: 0;
+    }"
+  `)
+  expect(
+    await run([
+      'perspective',
+      '-perspective',
+      'perspective-potato',
+      'perspective-123',
+      'perspective-normal/foo',
+      'perspective-dramatic/foo',
+      'perspective-none/foo',
+      'perspective-[456px]/foo',
+    ]),
+  ).toEqual('')
 })
 
 test('translate-z', async () => {

v4 alpha.32 translate regression
<!-- Please provide all of the information requested below. We're a small team and without all of this information it's not possible for us to help and your bug report will be closed. -->

**What version of Tailwind CSS are you using?**

v4 alpha 32

**What build tool (or framework if it abstracts the build tool) are you using?**

vite

**What version of Node.js are you using?**

v22

**What browser are you using?**

Edge

**What operating system are you using?**

Windows

**Reproduction URL**

A Tailwind Play link or public GitHub repo that includes a minimal reproduction of the bug. **Please do not link to your actual project**, what we need instead is a _minimal_ reproduction in a fresh project without any unnecessary code. This means it doesn't matter if your real project is private/confidential, since we want a link to a separate, isolated reproduction anyways.

A reproduction is **required** when filing an issue — any issue opened without a reproduction will be closed and you'll be asked to create a new issue that includes a reproduction. We're a small team and we can't keep up with the volume of issues we receive if we need to reproduce each issue from scratch ourselves.

**Describe your issue**

ok alpha 31:
<img width="299" alt="image" src="https://github.com/user-attachments/assets/610536c9-ce65-4997-a88a-d2ed94103b4f">

Not ok alpha 32:
<img width="302" alt="image" src="https://github.com/user-attachments/assets/51cb1aac-2d14-4293-a344-26af52a0f44a">


@madmoizo Thanks for the report! I can reproduce this issue as well. Looking into it!